86146-54-5

Basic information

• Product Name: Tyr(Me)¹-dermorphin
• CAS NO: 86146-54-5
• Molecular Weight: 816.911
• Mol File: 86146-54-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Tyr(Me)¹-dermorphin(CAS DataBase Reference)
• NIST Chemistry Reference: Tyr(Me)¹-dermorphin(86146-54-5)
• EPA Substance Registry System: Tyr(Me)¹-dermorphin(86146-54-5)

Safety Data

• Hazardous Substances Data: 86146-54-5(Hazardous Substances Data)

Upstream product

• 4530-20-5 BOC-glycine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 2130-96-3 O-benzyl-N-tert-butoxycarbonyl-L-tyrosine 
• 23680-31-1 BOC-O-benzyl-L-serine 

Relevant articles and documents

Structure-Activity Studies of Dermorphin. Synthesis and Some Pharmacological Data of Dermorphin and Its 1-Substiituted Analogues

Dermorphin and its analogues substituted at position 1 by N-acetyltyrosine, O-methyltyrosine, phenylalanine, D-phenylalanine, or alanine were obtained by solid-phase peptide synthesis.Their pharmacological effects were studied in vitro by the guinea pig ileum method and in vivo by the hot plate method, and the results were compared with those of morphine.The most pronounced activity was shown for dermorphin.A radioreceptor study showed a moderate affinity of dermorphin and its Tyr(Me)1 analogue for the opiate receptor sites from striatal homogenates.