86162-90-5

Basic information

• Product Name: methyl (2,6-dinitrophenyl)acetate
• Synonyms: methyl (2,6-dinitrophenyl)acetate
• CAS NO: 86162-90-5
• Molecular Weight: 240.172
• Mol File: 86162-90-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: methyl (2,6-dinitrophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2,6-dinitrophenyl)acetate(86162-90-5)
• EPA Substance Registry System: methyl (2,6-dinitrophenyl)acetate(86162-90-5)

Safety Data

• Hazardous Substances Data: 86162-90-5(Hazardous Substances Data)

Upstream product

• 606-21-3 1-chloro-2,6-dinitrobenzene 
• 86162-89-2 dimethyl (2,6-dinitrophenyl)malonate 
• 67-56-1 methanol 
• 99-65-0 meta-dinitrobenzene 
• 96-32-2 bromoacetic acid methyl ester 
• 5199-50-8 methyl 2-iodoacetate 

Downstream Products

• 1228170-53-3 C₁₃H₁₄N₂O₈ 
• 1341124-14-8 C₉H₁₂N₂O₂ 
• 1338064-97-3 2-(4-(trifluoromethyl)phenyl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-5-yl)acetamide 
• 1341124-13-7 1-(4-(trifluoromethyl)-2-(piperidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea 
• 1341124-12-6 1-(4-(trifluoromethyl)-2-(pyrrolidin-1-yl)benzyl)-3-(2-oxoindolin-4-yl)urea 
• 1341124-11-5 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2-oxoindolin-4-yl)urea 
• 848679-01-6 N-(2-oxo-2,3-dihydro-1H-indol-4-yl)-N'-[4-(trifluoromethyl)benzyl]urea 
• 61394-51-2 4-nitro-1,3-dihydroindol-2-one 
• 37777-63-2 (2,6-dinitro-phenyl)-acetic acid 
• 141-78-6 ethyl acetate 
• 57764-45-1 3-Carbomethoxy-4-hydroxybenzisoxazol 
• 57764-44-0 3-Carbomethoxy-4-aminobenzisoxazol 
• 86162-98-3 3-(4-nitrophenyl)-4-(p-tolylsulfonyl)-2,2a,3,4-tetrahydro-1H-pyrrolo<4.3.2-cd>indol-2-one 
• 86162-97-2 4-Methyl-N-{2-oxo-3-[1-(3,4,5-trimethoxy-phenyl)-meth-(Z)-ylidene]-2,3-dihydro-1H-indol-4-yl}-benzenesulfonamide 

Relevant articles and documents

TRPV1 vanilloid receptor antagonists with a bicyclic portion

The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.

Synthesis of 2-(2,6-dinitrophenyl)malonates, -acetates and acetonitrile by copper-mediated vicarious nucleophilic substitution

A regioselective, vicarious nucleophilic substitution of 1,3- dinitrobenzene with α-bromo- and iodocarbanions proceeds in the presence of copper(1) tert-butoxide and pyridine giving 2,6-dinitrophenylmalonates, 2,6- dinitrophenylacetates or 2,6-dinitrophenylacetonitrile as the only isomers from bromomalonate esters, bromoacetate esters, iodoacetate esters or iodoacetonitrile, respectively. Without copper(I) tert-butoxide, the 4- substituted isomer is the only product. We believe that the reaction proceeds via a σ-adduct of 1,3-dinitrobenzene and halocarbanion from which hydrogen and halogen are eliminated. This elimination is dependent upon the concentration of copper(I) tert-butoxide.