861658-15-3

Basic information

• Product Name: 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate
• CAS NO: 861658-15-3
• Molecular Weight: 275.302
• Mol File: 861658-15-3.mol
• Article Data: 71

Chemical Properties

• CAS DataBase Reference: 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate(861658-15-3)
• EPA Substance Registry System: 1,5-dimethyl 2-[(t-butoxycarbonyl)amino]pentanedioate(861658-15-3)

Safety Data

• Hazardous Substances Data: 861658-15-3(Hazardous Substances Data)

Usage

Chemical class

Amino dicarboxylic acids and derivatives

Molecular weight

229.29 g/mol

Appearance

Colorless to pale yellow solid or liquid

Solubility

Soluble in organic solvents such as ethanol, methanol, and acetonitrile

Melting point

Not readily available, but likely to be low due to the presence of flexible carbon chain

Boiling point

Not readily available, but likely to be relatively high due to the presence of multiple functional groups

Density

Not readily available, but likely to be less than 1 g/cm3 due to the presence of a carbon chain

Functional groups

Carboxylic acid, amino, and t-butoxycarbonyl protecting group

Reactivity

Reacts with various reagents to form peptide and protein derivatives

Applications

Organic synthesis
Preparation of peptide and protein derivatives
Production of pharmaceuticals, agrochemicals, and other fine chemicals
Potential applications in medicine and biochemistry due to structural similarity to natural amino acids and ability to modify peptide and protein properties

Safety

Handle with care, as it may be harmful if inhaled, ingested, or if it comes into contact with the skin

Storage

Store in a cool, dry, and well-ventilated area, away from heat, sparks, and open flames

Stability

Stable under normal conditions, but may decompose upon exposure to heat, light, or moisture

Regulatory status

Not readily available, but it may be subject to specific regulations depending on its intended use and concentration in a given product.

Upstream product

• 6525-53-7 L-glutamic acid dimethyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 67-56-1 methanol 
• 617-65-2 Glutamic acid 
• 6525-53-7 glutamic acid dimethyl ether 
• 120341-33-5 1-[(tert-butoxy)-carbonyl-amino]propane-1,3-dicarboxylic acid 
• 861657-91-2 rac-1-(tert-butyl) 2-methyl 5-oxopyrrolidine-1,2-dicarboxylate 
• 6893-26-1 D-Glutamic acid 
• 16422-27-8 1,5-dimethyl (2R)-2-aminopentanedioate 
• 2419-94-5 Boc-Glu 
• 74-88-4 methyl iodide 
• 56-86-0 L-glutamic acid 
• 13726-85-7 Boc-Gln-OH 
• 56-85-9 L-glutamine 

Downstream Products

• 334618-23-4 3-(R)-aminopiperidine dihydrochloride 
• 72086-72-7 N-tert-butoxycarbonylglutamic acid methyl ester 

Relevant articles and documents

[1,2] Boc migration during pyroglutamate alkylations

Treatment of N-Boc protected pyroglutamates with strong bases lead to a Boc migration from the N-atom to the C2 position when no or poor electrophiles are being used.

L-glutamic acid derivative and synthesis method and application thereof

The invention belongs to the technical field of synthesis of medical and traditional Chinese medicine intermediates, and discloses an L-glutamic acid derivative and a synthesis method and applicationthereof. All the steps in the synthesis method are simple and in order , the obtained L-dimethyl glutamate hydrochloride oily matter is directly put into the next step of reaction through a one-pot method, L-dimethyl glutamate hydrochloride solids do not need to be obtained, the use of all the raw materials can be effectively reduced, and the cost is reduced; ethyl acetate is selected as a reaction solvent and can be effectively recycled, the utilization rate of the ethyl acetate is remarkably increased, and pollution to the environment is reduced; a final product is obtained in a crystallization manner so that the convenience and the storage convenience during transportation are improved, and the quality and the yield of the product can be further improved. The technical scheme of the synthesis method is complete and simple, the produced product is high in crystallization yield and better in quality, the overall yield of the product is conveniently, rapidly, scientifically and effectively increased to 85% or above, and raw materials are provided for research and development of new drugs.

Zelkovamycin is an OXPHOS Inhibitory Member of the Argyrin Natural Product Family

Natural products (NPs) are an important inspirational source for developing drugs and chemical probes. In 1999, the group of ōmura reported the constitutional elucidation of zelkovamycin. Although largely unrecognized so far, this NP displays structural s