861896-81-3

Basic information

• Product Name: (2R)-4-oxo-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid
• Synonyms: (2R)-4-oxo-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid
• CAS NO: 861896-81-3
• Molecular Weight: 297.354
• Mol File: 861896-81-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R)-4-oxo-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-4-oxo-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid(861896-81-3)
• EPA Substance Registry System: (2R)-4-oxo-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid(861896-81-3)

Safety Data

• Hazardous Substances Data: 861896-81-3(Hazardous Substances Data)

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 98-86-2 acetophenone 
• 298-12-4 Glyoxilic acid 
• 17812-07-6 Benzoylacrylic acid 

Downstream Products

• 583-06-2 3-benzoylacrylic acid 
• 383418-30-2 (1R,3S)-dodecanoic acid (3-hydroxy-1-hydroxymethyl-3-phenylpropyl)amide 
• 384835-42-1 (1R,3R)-N-(3-hydroxy-1-hydroxymethyl-3-phenylprop-1-yl)dodecanamide 
• 1273328-66-7 C₁₈H₂₁NO₃ 
• 1273328-94-1 (1S,3R)-3-((R)-1-phenylethylamino)-1-phenylbutane-1,4-diol 
• 1273328-86-1 (1R,3R)-3-((R)-1-phenylethylamino)-1-phenylbutane-1,4-diol 
• 861896-84-6 (2R,4S)-4-hydroxy-4-phenyl-2-{[(1R)-1-phenylethyl]amino}butanoic acid 

Relevant articles and documents

The first example of a crystallization-induced asymmetric transformation (CIAT) in the Mannich reaction

The novel synthesis of highly enantioenriched N-substituted α-amino-γ-alkyl(aryl)-γ-oxobutanoic acids is described. The process involves the combination of a crystallization-induced asymmetric transformation (CIAT) and the Mannich reaction. The role of retro-Mannich and retro-Michael reactions in the mechanism of the highly stereoselective transformation is also discussed.