861931-75-1

Basic information

• Product Name: (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester
• Synonyms: (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester;tert-butyl 2-bromo-5-fluorophenylcarbamate
• CAS NO: 861931-75-1
• Molecular Formula: C₁₁H₁₃BrFNO₂
• Molecular Weight: 290.1288232
• Mol File: 861931-75-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester(861931-75-1)
• EPA Substance Registry System: (2-BroMo-5-fluoro-phenyl)-carbaMic acid tert-butyl ester(861931-75-1)

Safety Data

• Hazardous Substances Data: 861931-75-1(Hazardous Substances Data)

Upstream product

• 446-09-3 2-bromo-5-fluoronitrobenzene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1003-99-2 2-bromo-5-fluoroaniline 
• 81740-18-3 N-(tert-butyloxycarbonyl)-meta-fluoroaniline 

Downstream Products

• 1057720-44-1 tert-butyl N-(2-bromo-5-fluorophenyl)-N-(prop-2-ynyl)carbamate 
• 1186637-38-6 tert-butyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenylcarbamate 
• 1370735-32-2 tert-butyl 2-bromo-5-fluorophenyl(((chloromethyl)dimethylsilyl)methyl)carbamate 

Relevant articles and documents

Synthesis method and intermediate for 2-bromo-5-fluoro-4-nitroaniline

The invention discloses a synthesis method and an intermediate for 2-bromo-5-fluoro-4-nitroaniline. The synthesis method for 2-bromo-5-fluoro-4-nitroaniline comprises the step of carrying out a nitration reaction on 2-bromo-5-fluoroaniline and a nitration reagent to generate the 2-bromo-5-fluoro-4-nitroaniline, or comprises the following steps: reacting the 2-bromo-5-fluoroaniline with an amino protection reagent to obtain amino-protected 2-bromo-5-fluoroaniline, then carrying out the nitration reaction on the amino-protected 2-bromo-5-fluoroaniline and the nitration reagent to generate a nitration product that is the intermediate, and finally, removing the amino protection group from the nitration product to obtain the 2-bromo-5-fluoro-4-nitroaniline. The synthesis method has the advantages of high reaction yield, high product purity and easily available raw materials.

Development of a Br?nsted acid-promoted arene-ynamide cyclization toward the total syntheses of marinoquinolines A and C and aplidiopsamine A

(Chemical Equation Presented) A Br?nsted acid-promoted arene-ynamide cyclization has been developed to construct the 3H-pyrrolo[2,3-c]quinolines. This reaction consists of the generation of a highly reactive keteniminium intermediate from arene-ynamide activated by a Br?nsted acid and electrophilic aromatic substitution reaction to give arene-fused quinolines in high yields. This methodology enabled facile access to marinoquinolines A and C and aplidiopsamine A.

Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: A route to functionalized indolines, isoquinolinones, and indoles

A general procedure for the palladium-catalyzed annulation of substituted haloanilines with norbornadiene gives functionalized indolines in 51-98% yield. These indolines can be rapidly converted to benzenoid- substituted indoles and tricyclic indolines. Extension to the use of substituted halobenzamides gives functionalized isoquinolinones in up to 86% yield.