861968-39-0

Basic information

• Product Name: (1R,2R)-3-tert-butyldimethylsilyloxy-2-(N,N-dimethylamino)-1-p-nitrophenyl-1-propanol
• Synonyms: (1R,2R)-3-tert-butyldimethylsilyloxy-2-(N,N-dimethylamino)-1-p-nitrophenyl-1-propanol
• CAS NO: 861968-39-0
• Molecular Weight: 354.522
• Mol File: 861968-39-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (1R,2R)-3-tert-butyldimethylsilyloxy-2-(N,N-dimethylamino)-1-p-nitrophenyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-3-tert-butyldimethylsilyloxy-2-(N,N-dimethylamino)-1-p-nitrophenyl-1-propanol(861968-39-0)
• EPA Substance Registry System: (1R,2R)-3-tert-butyldimethylsilyloxy-2-(N,N-dimethylamino)-1-p-nitrophenyl-1-propanol(861968-39-0)

Safety Data

• Hazardous Substances Data: 861968-39-0(Hazardous Substances Data)

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 18867-45-3 (1R,2R)-(-)-2-(dimethylamino)-1-(4-nitrophenyl)-1,3-propanediol 

Downstream Products

• 1031703-03-3 (1R,2R)-1-acetoxy-3-(tert-butyldimethylsiloxy)-2-(dimethylamino)-1-(4-nitrophenyl)propane 

Relevant articles and documents

waylen apperception HIV reverse transcriptase inhibitors in accordance with the law of the process for the asymmetric synthesis of one-pot synthesis (by machine translation)

The invention relates to a novel one pot method asymmetric synthesis process of a (S)-6-chlorine-4-cylopropyl ethylnen-4-trifluoromethyl-1,4-dihydro-2H-1,3-benzoxazine-2-ketone (Efavirenz) compound, the compound can be used as an reverse transcriptase inhibitor for human immunodeficiency virus (HIV). The invention also relates to a novel aminoalcohol ligand used for the process.

AN AMINO ALCOHOL LIGAND AND ITS USE IN PREPARATION OF CHIRAL PROPARGLIC TERTIARY ALKOHOLS AND TERTIARY AMINES VIA ENANTIOSELECTIVE ADDITON REACTION

The invention disclosed a new process of asymmetric alkynylation of ketone or ketimine, involving the chiral ligand-mediated asymmetric addition of zinc or copper acetylide to a trifluoromethyl ketone or ketimine intermediate to give a chiral tertiary pro