86233-09-2Relevant articles and documents
Preparation method of Ledipasvir key intermediate
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, (2019/01/16)
The invention provides a preparation method of a Ledipasvir key intermediate 7-bromo-2-(chloracetyl)-9,9-difluorofluorene. 4-bromaniline is used as an initial raw material, by virtue of aminoacetylation and benzyl-chlorophene alkylation, acetyl in the concentrated hydrochloric acid is removed, the diazotization coupling is performed under the catalysis of copper to obtain 2-bromofluorene, then the2-bromofluorene and a fluorine reagent react to obtain 7-bromo-9,9-difluorofluorene, finally the 7-bromo-9,9-difluorofluorene has Friedel-Crafts acylation reaction with chloroacetyl chloride to obtain an intermediate 7-bromo-2-(chloracetyl)-9,9-difluorofluorene. The preparation method of the invention is short in synthetic route, safe in process, simple and convenient in operation, low in raw material cost and capable of meeting the industrialized production requirement.
2-(Imidazol-1-yl)benzophenones
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, (2008/06/13)
Compounds of formula II SPC1 and its phthalimide derivative III: SPC2 wherein R0 and R1 are hydrogen or alkyl of 1 to 3 carbon atoms, inclusive; wherein R2 is hydrogen, chloro, fluoro, or trifluoromethyl; wherein R3/
