86235-82-7

Basic information

• Product Name: methyl 4-(3-oxo-3-phenylpropanoyl)benzoate
• CAS NO: 86235-82-7
• Molecular Formula: C₁₇H₁₄O₄
• Molecular Weight: 282.2907
• Mol File: 86235-82-7.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 461.7°C at 760 mmHg
• Flash Point: 205.9°C
• Density: 1.202g/cm³
• Vapor Pressure: 1.05E-08mmHg at 25°C
• Refractive Index: 1.575
• CAS DataBase Reference: methyl 4-(3-oxo-3-phenylpropanoyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(3-oxo-3-phenylpropanoyl)benzoate(86235-82-7)
• EPA Substance Registry System: methyl 4-(3-oxo-3-phenylpropanoyl)benzoate(86235-82-7)

Safety Data

• Hazardous Substances Data: 86235-82-7(Hazardous Substances Data)

Upstream product

• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 98-86-2 acetophenone 
• 66737-07-3 1-(4-methoxycarbonylphenyl)-3-phenylpropynone 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 932-90-1 Benzaldoxime 
• 56893-25-5 methyl 4-(2-bromoacetyl)benzoate 

Downstream Products

• 52380-62-8 1-(4-methoxycarbonylphenyl)-2-phenylethane-1,2-dione 
• 182162-14-7 4-(2,2-Dimethyl-3-oxo-3-phenyl-propionyl)-benzoic acid methyl ester 
• 75794-55-7 4-(3'-phenyl-3'-oxopropionyl)benzoic acid 
• 194040-98-7 {4-[4-(3-Oxo-3-phenyl-propionyl)-benzoylamino]-butyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

A metal-free strategy for the cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol

Here, we report a metal-free approach for the construction of methylene-bridged bis-1,3-dicarbonyl compounds via cross-dehydrogenative coupling of 1,3-dicarbonyl compounds with 2-methoxyethanol. In addition, we have extended this methodology to synthesize tetra-substituted pyridine derivatives using 1,3-dicarbonyl, 2-methoxyethanol and NH4OAc in one step. The key advantages include accepting a wide range of substrates, utilizing O2 as the sole oxidant, and synthesizing biologically active compounds such as 1,4-dihydropyridine and pyrazole. This journal is

An effective preparation of both 1,3-diketones and nitriles from alkynones with oximes as hydroxide sources

An effective phosphine-catalyzed protocol has been established for the syntheses of 1,3-diketones and nitriles from alkynones with oximes as hydroxide surrogates. This method features the use of a phosphine catalyst, compatibility with various functional groups and ambient temperature, which makes this approach very practical. A plausible mechanism was proposed.

Transition-metal-free formal decarboxylative coupling of ?±-oxocarboxylates with ?±-bromoketones under neutral conditions: A simple access to 1,3-diketones

A transition-metal-free formal decarboxylative coupling reaction between ?±-oxocarboxylates and ?±-bromoketones to synthesize 1,3-diketone derivatives is presented. In this reaction, a broad scope of substrates can be employed, and neither a metal-based reagent nor an additional base is required. DFT calculations reveal that this reaction proceeds through a coupling followed by decarboxylation mechanism and the ?±-bromoketone unprecedentedly serves as a nucleophile under neutral conditions. The rate-determining step is an unusual hydrogen-bond-assisted enolate formation by thermolysis.