862540-80-5

Basic information

• Product Name: 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide
• Synonyms: 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide
• CAS NO: 862540-80-5
• Molecular Weight: 732.029
• Mol File: 862540-80-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide(862540-80-5)
• EPA Substance Registry System: 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide(862540-80-5)

Safety Data

• Hazardous Substances Data: 862540-80-5(Hazardous Substances Data)

Upstream product

• 921598-21-2 2-[3-(2-amino-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-3-yl)methyl]acetamide 
• 865589-70-4 [3-(2-tert-butoxycarbonylamino-2-methylpropyl)phenyl]acetic acid 
• 921598-16-5 ethyl [3-(2-tert-butoxycarbonylamino-2-methylpropyl)phenyl]acetate 
• 921598-18-7 {3-[2-(2,2,2-trichloro-acetylamino)-2-methyl-propyl]-phenyl}-acetic acid 
• 861448-90-0 ethyl 2-[3-(2-amino-2-methylpropyl)phenyl]acetate hydrogen (2R,3R)-2,3-bis[(4-methylbenzoyl)oxy]succinate 
• 865589-97-5 3'-(aminomethyl)biphenyl-4-ol hydrochloride 
• 808768-96-9 2-[3-(2-hydroxy-2-methylpropyl)phenyl]acetic acid 
• 333796-54-6 (1R)-1-[3-amino-4-(phenylmethoxy)phenyl]-2-bromoethan-1-ol 
• 170687-82-8 N-{2-(benzyloxy)-5-[(1R)-2-bromo-1-hydroxyethyl]phenyl}methane sulfonamide 
• 188690-82-6 (R)-2-bromo-1-(4-benzyloxy-3-nitrophenyl)ethanol 
• 14347-08-1 1-[4-Phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanone 
• 14347-15-0 1-[4-phenylmethoxy-3-aminophenyl]ethanone 
• 14347-25-2 2-Bromo-1-[4-phenylmethoxy-3-[(methylsulfonyl)amino]phenyl]ethanone 
• 43229-01-2 4-benzyloxy-3-nitrophenacyl bromide 

Relevant articles and documents

Development of a potential manufacturing route to PF-00610355: A novel inhaled β2-adrenoreceptor agonist

The development of a practical, scalable route to PF-00610355 (8) is described. In this convergent approach, amine 9 is coupled to protected bromohydrin 1 to give the doubly protected intermediate 26. TBS-Deprotection of 26 affords the benzyl protected pe

PROCESS FOR THE PREPARATION OF SULFONAMIDE DERIVATIVES

The invention relates to a process for the preparation of compounds of formula (I) wherein Q1 is a group selected from formulae (II and (III) and a group *-NR6 -Q2-A or, if appropriate, their pharmaceutically acceptable sa