862789-58-0

Basic information

• Product Name: (1R,2R)-2-nitro-1-phenylpropan-1-ol
• Synonyms: (1R,2R)-2-nitro-1-phenylpropan-1-ol
• CAS NO: 862789-58-0
• Molecular Weight: 181.191
• Mol File: 862789-58-0.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: (1R,2R)-2-nitro-1-phenylpropan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-nitro-1-phenylpropan-1-ol(862789-58-0)
• EPA Substance Registry System: (1R,2R)-2-nitro-1-phenylpropan-1-ol(862789-58-0)

Safety Data

• Hazardous Substances Data: 862789-58-0(Hazardous Substances Data)

Upstream product

• 79-24-3 Nitroethane 
• 100-52-7 benzaldehyde 
• 529-20-4 2-methylphenyl aldehyde 
• 26251-08-1 2-nitro-1-phenylpropan-1-ol 

Relevant articles and documents

Stereoselective Catalytic Synthesis of Active Pharmaceutical Ingredients in Homemade 3D-Printed Mesoreactors

3D-printed flow reactors were designed, fabricated from different materials (PLA, HIPS, nylon), and used for a catalytic stereoselective Henry reaction. The use of readily prepared and tunable 3D-printed reactors enabled the rapid screening of devices with different sizes, shapes, and channel dimensions, aimed at the identification of the best-performing reactor setup. The optimized process afforded the products in high yields, moderate diastereoselectivity, and up to 90 % ee. The method was applied to the continuous-flow synthesis of biologically active chiral 1,2-amino alcohols (norephedrine, metaraminol, and methoxamine) through a two-step sequence combining the nitroaldol reaction with a hydrogenation. To highlight potential industrial applications of this method, a multistep continuous synthesis of norephedrine has been realized. The product was isolated without any intermediate purifications or solvent switches.

Rhodium(I) complexes containing 9,10-phenanthrenequinone-N-substituted thiosemicarbazone ligands: Synthesis, structure, DFT study and catalytic diastereoselective nitroaldol reaction studies

Abstract New rhodium(I) complexes [Rh(CO)(L)] (1-3) were prepared by the reaction of [RhCl(CO)(PPh3)2] with 9,10-phenanthrenequinone-N-substituted thiosemicarbazones (HL1-3) and characterized by elemental and spectral anal

Design of a chiral secondary amine ligand for copper-catalyzed anti -selective Henry reaction

A series of chiral binaphthyl-containing diphenylethylenediamine (binaph-dpen) ligands was designed and synthesized for the copper-catalyzed asymmetric Henry reaction. The N-monobenzyl (S)-binaph-(R,R)-dpen ligand, with a secondary amine portion, promoted