862847-08-3Relevant articles and documents
Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)
Rowbottom, Martin W.,Vickers, Troy D.,Dyck, Brian,Tamiya, Junko,Zhang, Mingzhu,Zhao, Liren,Grey, Jonathan,Provencal, David,Schwarz, David,Heise, Christopher E.,Mistry, Monica,Fisher, Andrew,Dong, Teresa,Hu, Tao,Saunders, John,Goodfellow, Val S.
, p. 3439 - 3445 (2007/10/03)
A novel series of bis-aminopyrrolidine ureas containing either a 4-biphenylcarboxmide or 5-phenyl-2-thiophenecarboxamide group have been identified as potent and functional antagonists of the melanin-concentrating hormone receptor-1. Syntheses and SAR are