862847-44-7

Basic information

• Product Name: BOC-L-LYS(IVDDE)-OH
• Synonyms: BOC-L-LYS(IVDDE)-OH;N-ALPHA-TERT-BUTYLOXYCARBONYL-N-EPSILON-[1-(4,4-DIMETHYL-2,6-DIOXOCYCLOHEX-1-YLIDENE)-3-METHYLBUTYL]-L-LYSINE;N-alpha-t-Butyloxycarbonyl-N-epsilon-[1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl]-L-lysine;Boc-Lys(Mtt)-OH·DCHA;Nα-Boc-Nε-1-(4,4-dimethyl-2,6-dioxocyclo-hex-1-ylidene)-3-methylbutyl-L-lysine≥ 98% (HPLC);Nα-Boc-Nε-ivDde-L-Lysine
• CAS NO: 862847-44-7
• Molecular Formula: C₂₄H₄₀N₂O₆
• Molecular Weight: 452.58
• Mol File: 862847-44-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BOC-L-LYS(IVDDE)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-L-LYS(IVDDE)-OH(862847-44-7)
• EPA Substance Registry System: BOC-L-LYS(IVDDE)-OH(862847-44-7)

Safety Data

• Hazardous Substances Data: 862847-44-7(Hazardous Substances Data)

Usage

Chemical Properties

White crystalline powder

Upstream product

• 13734-28-6 Boc-Lys-OH 
• 172611-72-2 2-(1-hydroxy-3-methylbutylidene)-5,5-dimethylcyclohexane-1,3-dione 

Downstream Products

• 919281-76-8 C₁₉H₃₂N₂O₄ 
• 1609570-02-6 C₃₆H₄₇N₃O₇ 
• 1609570-04-8 C₄₃H₅₄N₄O₇ 
• 1609570-06-0 C₅₀H₅₇N₅O₁₁ 
• 1609570-09-3 C₅₃H₇₂N₆O₁₀ 
• 1609570-11-7 C₄₉H₆₃ClN₆O₉ 
• 1609570-14-0 C₆₁H₇₀N₆O₁₂ 

Relevant articles and documents

Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action

Recent years have seen tremendous progress in the design and study of molecular imaging geared towards biological and biomedical applications. The expression or activity of specific enzymes including proteases can be monitored by cutting edge molecular imaging techniques. Cathepsin B plays key roles in tumor progression via controlled degradation of extracellular matrix. Consequently, this protease has been attracting significant attention in cancer research, and many imaging probes targeting its activity have been developed. Here, we describe the design, synthesis and evaluation of two novel near infrared (NIR) fluorescent probes for detection of cathepsin B activity with different turn-ON mechanisms. One probe is based on an ICT activation mechanism of a donor-two-acceptor π-electron dye system, while the other is based on the FRET mechanism obtained by a fluorescent dye and a quencher. The two probes exhibit significant fluorescent turn-ON response upon cleavage by cathepsin B. The NIR fluorescence of the ICT probe in its OFF state was significantly lower than that of the FRET-based probe. This effect results in a higher signal-to-noise ratio and consequently increased sensitivity and better image contrast.