862906-97-6

Basic information

• Product Name: 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-oxo-3-phenyl-, 1,1-dimethylethyl ester
• CAS NO: 862906-97-6
• Molecular Formula: C19H19NO3
• Molecular Weight: 309.365
• Mol File: 862906-97-6.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-oxo-3-phenyl-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-oxo-3-phenyl-, 1,1-dimethylethyl ester(862906-97-6)
• EPA Substance Registry System: 1H-Indole-1-carboxylic acid, 2,3-dihydro-2-oxo-3-phenyl-, 1,1-dimethylethyl ester(862906-97-6)

Safety Data

• Hazardous Substances Data: 862906-97-6(Hazardous Substances Data)

Upstream product

• 108-86-1 bromobenzene 
• 100-59-4 phenylmagnesium chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 91-56-5 indole-2,3-dione 
• 100-58-3 phenylmagnesium bromide 
• 1402800-34-3 tert-butyl 3-hydroxy-2-oxo-3-phenylindoline-1-carboxylate 
• 160858-75-3 1-tert-butoxycarbonylisatin 
• 214610-10-3 N-boc-2-oxyindole 
• 3456-79-9 3-phenyloxindole 
• 862907-25-3 1-(tert-butoxycarbonyl)-2-oxo-3-phenylindolin-3-yl tert-butyl carbonate 
• 139018-14-7 3-hydroxy-3-phenyl-1,3-dihydro-indol-2-one 

Downstream Products

• 1229652-86-1 tert-butyl-3-(hydroxymethyl)-2-oxo-3-phenylindoline-1-carboxylate 
• 1289108-19-5 (R)-ethyl 2-(1,3-dioxoisoindolin-2-yl)-3-((S)-2-oxo-3-phenylindolin-3-yl)propanoate 
• 1289108-21-9 C₂₃H₂₄N₂O₅ 
• 1289108-23-1 (R)-2-acetamido-3-((S)-2-oxo-3-phenylindolin-3-yl)propanoic acid 
• 1289108-24-2 (R)-ethyl 2-acetamido-3-((S)-2-oxo-3-phenylindolin-3-yl)propanoate 
• 1289108-68-4 tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate 
• 1289108-15-1 tert-butyl 3-(2-(1,3-dioxoisoindolin-2-yl)-3-ethoxy-3-oxopropyl)-2-oxo-3-phenylindoline-1-carboxylate 
• 1040749-29-8 (S)-tert-butyl 3-fluoro-2-oxo-3-phenylindoline-1-carboxylate 
• 1273020-46-4 (S)-tert-butyl 3-chloro-2-oxo-3-phenylindoline-1-carboxylate 
• 912845-16-0 tert-butyl 3-chloro-2-oxo-3-phenylindoline-1-carboxylate 
• 1271489-18-9 tert-butyl 3-(benzoyloxy)-2-oxo-3-phenylindoline-1-carboxylate 
• 1271489-17-8 tert-butyl (S)-3-(benzoyloxy)-2-oxo-3-phenylindoline-1-carboxylate 
• 900811-77-0 3-phenyl-3-hydroxy-1,3-dihydro-indol-2-one 

Relevant articles and documents

Electrochemical Umpolung C-H Functionalization of Oxindoles

Herein, we present a general electrochemical method to access unsymmetrical 3,3-disubstituted oxindoles by direct C-H functionalization where the oxindole fragment behaves as an electrophile. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.

Asymmetric organocatalytic α-amination of 2-oxindoles with bis(2,2,2-trichloroethyl)azo-dicarboxylate

An enantioselective electrophilic amination of 3-substituted-2-oxindoles is reported, using bis(2,2,2-trichloroethyl)azo-dicarboxylate and commercially available Cinchona alkaloid organocatalysts. The best results were obtained in the reaction of 3-aryl s

Organocatalytic stereoselective conjugate addition of 3-substituted oxindoles with in situ generated ortho-quinone methides

A novel method for the stereoselective conjugate addition of 3-substituted oxindoles to in situ generated o-QMs was described. This process was catalyzed efficiently by a cinchonidine-derived squaramide catalyst in oil-water phase, furnishing the corresponding 3,3-disubsituted oxindole derivatives in moderate to high yields (up to 98%) with high stereoselectivities (up to 95% ee, 15.4:1 dr). The utility of this reaction was also investigated by the gram-scale synthesis and derivatization of one of the products.