863225-15-4

Basic information

• Product Name: trans-[NiCl(4-C₄N₂ClF₂)(PPh₃)2]
• CAS NO: 863225-15-4
• Molecular Weight: 768.232
• Mol File: 863225-15-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: trans-[NiCl(4-C₄N₂ClF₂)(PPh₃)2](CAS DataBase Reference)
• NIST Chemistry Reference: trans-[NiCl(4-C₄N₂ClF₂)(PPh₃)2](863225-15-4)
• EPA Substance Registry System: trans-[NiCl(4-C₄N₂ClF₂)(PPh₃)2](863225-15-4)

Safety Data

• Hazardous Substances Data: 863225-15-4(Hazardous Substances Data)

Upstream product

• 1295-35-8 bis(1,5-cyclooctadiene)nickel ⁽⁰⁾ 
• 697-83-6 2,4,6-trifluoro-5-chloropyrimidine 
• 603-35-0 triphenylphosphine 
• 75-77-4 chloro-trimethyl-silane 
• 863225-14-3 trans-[NiF(4-C₄N₂ClF₂)(PPh₃)2] 

Relevant articles and documents

Catalytic C-C coupling reactions at nickel by C-F activation of a pyrimidine in the presence of a C-Cl bond: The crucial role of highly reactive fluoro complexes

Treatment of [Ni(COD)2] (COD = 1,5-cyclooctadiene) with 5-chloro-2,4,6-trifluoropyrimidine (1) in the presence of PiPr 3 or PPh3 effects the formation of the fluoro complexes trans-[NiF(4-C4N2ClF2)(PiPr 3)2] (3) and trans-[NiF(4-C4N 2ClF2)(PPh3)2] (4). The chloro complex trans-[NiCl(4-C4N2ClF2)(PPh 3)2] (5) can be prepared by reaction of 4 with Me 3SiCl. In contrast, a reaction of 1 with [Pd(PPh3) 4] leads to the insertion of a {Pd(PPh3)2} unit into the C-Cl bond yielding trans-[PdCl(5-C4N2F 3)(PPh3)2] (6). Treatment of 4 with an excess of TolB(OH)2 at 273 K results in the slow formation of trans-[NiF(4-C4N2TolClF)(PPh3)2] (7) and subsequently 5-chloro-2-fluoro-4,6-ditolylpyrimidine (8). Quenching of a solution of 7 with Me3SiCl leads to the chloro derivative trans-[NiCl(4-C4N2TolClF)(PPh3)2] (9). Treatment of 4 with PhB(OH)2 followed by addition of Me 3SiCl gives the complex trans-[NiCl(4-C4N 2PhClF)(PPh3)2] (10). In catalytic experiments, 1 is converted with the boronic acids TolB(OH)2, PhB(OH) 2, and p-F3CC6H4B(OH)2 into the 5-chloro-2-fluoro-4,6-diarylpyrimidines 8, 11, and 12 in 73%, 88%, and 37% yield, respectively, when 10% of 4 is employed as catalyst. The molecular structures of the complexes 5, 6, and 10 have been determined by X-ray crystallography. The studies reported in this paper represent the first catalytic C-C coupling reactions involving the activation of a C-F bond in the presence of a thermodynamically weaker C-Cl bond. They provide a route to access 5-chloro-2-fluoro-4,6-diarylpyrimidines, which have not been described before. There is considerable evidence that the presence of the fluoro ligand in 4 is crucial for the transmetalation step to occur and for the catalytic cycle to proceed.