86328-85-0

Basic information

• Product Name: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide
• Synonyms: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide
• CAS NO: 86328-85-0
• Molecular Weight: 267.392
• Mol File: 86328-85-0.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide(86328-85-0)
• EPA Substance Registry System: N-(cyclohexylmethyl)-4-methylbenzenesulfonamide(86328-85-0)

Safety Data

• Hazardous Substances Data: 86328-85-0(Hazardous Substances Data)

Upstream product

• 88-19-7 methyl 2-(aminosulfonyl)benzoate 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 2043-61-0 cyclohexanecarbaldehyde 
• 110-82-7 cyclohexane 
• 640-61-9 N-methyl-p-toluenesulfonylamide 
• 70-55-3 toluene-4-sulfonamide 
• 100-49-2 cyclohexylmethyl alcohol 
• 260975-29-9 (E)-N-cyclohexylmethylene-4-toluenesulfonamide 
• 593-71-5 Chloroiodomethane 
• 175355-34-7 N-(cyclohexylmethylene)-4-methylbenzenesulfonamide 
• 13698-06-1 N-(cyclohexa-1,4-dienylmethyl)-4-methylbenzenesulfonamide 

Downstream Products

• 3218-02-8 cyclohexylmethylamine 
• 260975-29-9 (E)-N-cyclohexylmethylene-4-toluenesulfonamide 

Relevant articles and documents

Diiodine-Triethylsilane System: Reduction of N-Sulfonyl Aldimines to N-Alkylsulfonamides

Because molecular iodine and hydrosilanes are stable to both air and moisture, reactions using these reagents are easy to operate and require mild reaction conditions. Molecular iodine and a hydrosilane were used to reduce N-sulfonyl aldimines to the corr

The: N -alkylation of sulfonamides with alcohols in water catalyzed by a water-soluble metal-ligand bifunctional iridium complex [Cp?Ir(biimH2)(H2O)][OTf]2

The iridium complex [Cp?Ir(biimH2)(H2O)][OTf]2 (Cp? = η5-pentamethylcyclopentadienyl, biimH2 = 2,2′-biimidazole) was synthesized and developed as a new-type of water-soluble metal-ligand bifunctional catalyst for the N-alkylation of poorly nucleophilic sulfonamides with alcohols in water. In the presence of catalyst (1 mol%) and Cs2CO3 (0.1 equiv.), a series of desirable products was obtained in 74-91% yields under microwave irradiation. Mechanistic experiments revealed that the presence of NH units in the imidazole ligand is crucially important for the catalytic activity of the iridium complex. Notably, this research would facilitate the process of water-soluble metal-ligand bifunctional catalysis for the hydrogen autotransfer process.

A synthetic N-alkyl sulfonamide derivatives

The invention discloses a method for synthesizing a N-alkyl sulfonamide derivative. The method comprises the following steps: adding a sulfonamide derivative, a water-soluble catalyst, an alkali, alcohol and a solvent into a reaction container; reacting the reaction mixture at 100-120 DEG C for several hours, cooling to room temperature; performing rotary evaporation to remove the solvent, and then separating by a column to obtain the target compound. The method of the invention starts from the sulfonamide derivative, and obtains the N-alkyl sulfonamide derivative through reaction with alcohol. The method of the invention adopts a water-soluble iridium complex as a catalyst; the reaction is carried out in water; and the target compound is obtained with a high yield. Therefore, the reaction meets the requirements for green chemistry, and the method has wide development prospects.