86346-43-2

Basic information

• Product Name: 2-NAPHTHALENECARBONYL CHLORIDE,1,2,3,4-TETRAHYDRO-
• Synonyms: 2-NAPHTHALENECARBONYL CHLORIDE,1,2,3,4-TETRAHYDRO-
• CAS NO: 86346-43-2
• Molecular Formula: C₁₁H₁₁ClO
• Molecular Weight: 194.66
• Mol File: 86346-43-2.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-NAPHTHALENECARBONYL CHLORIDE,1,2,3,4-TETRAHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NAPHTHALENECARBONYL CHLORIDE,1,2,3,4-TETRAHYDRO-(86346-43-2)
• EPA Substance Registry System: 2-NAPHTHALENECARBONYL CHLORIDE,1,2,3,4-TETRAHYDRO-(86346-43-2)

Safety Data

• Hazardous Substances Data: 86346-43-2(Hazardous Substances Data)

Upstream product

• 1914-65-4 tetralin-1-carboxylic acid 
• 53440-12-3 1,2,3,4-tetrahydro-2-naphthoic acid 
• 79-37-8 oxalyl dichloride 

Downstream Products

• 22099-65-6 3.4-Benzo-bicyclo[3.2.1]octenon-⁽⁷⁾ 
• 163221-77-0 N-(2-phenylethyl) 1,2,3,4-tetrahydro-2-naphthoic amide 

Relevant articles and documents

Rational design of a new class of toll-like receptor 4 (tlr4) tryptamine related agonists by means of the structure- and ligand-based virtual screening for vaccine adjuvant discovery

In order to identify novel lead structures for human toll-like receptor 4 (hTLR4) modulation virtual high throughput screening by a peta-flops-scale supercomputer has been performed. Based on the in silico studies, a series of 12 compounds related to tryptamine was rationally designed to retain suitable molecular geometry for interaction with the hTLR4 binding site as well as to satisfy general principles of drug-likeness. The proposed compounds were synthesized, and tested by in vitro and ex vivo experiments, which revealed that several of them are capable to stimulate hTLR4 in vitro up to 25% activity of Monophosphoryl lipid A. The specific affinity of the in vitro most potent substance was confirmed by surface plasmon resonance direct-binding experiments. Moreover, two compounds from the series show also significant ability to elicit production of interleukin 6.

BICYCLOANILINE DERIVATIVE

The invention relates to a compound of a general formula (I): wherein A1 and A2 each mean a nitrogen atom or an optionally-substituted methine group; Ring B means a 5-membered to 7-membered aliphatic ring, or a spiro or bicyclo ring formed from the aliphatic ring and any other 3-membered to 7-membered aliphatic ring; R1 means a hydrogen atom, or an optionally-substituted C1-C6 alkyl group, or an optionally-substituted aryl, aralkyl or heteroaryl group; R2 means an optionally-substituted aryl, aralkyl or heteroaryl group; and X means a group of =NH or =O, etc. Based on its excellent Wee1 kinase-inhibitory effect, the compound of the invention has cell growth-inhibitory effect and has an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.

NOVEL 2 AMINO-PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM, PHARMACEUTICAL COMPOSITIONS THEREOF

The present invention concerns novel 2 amino pyrimidine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.