863493-06-5Relevant articles and documents
Rational design, synthesis and structure-Activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 1: Lead identification
Xue, Chu-Biao,He, Xiaohua,Roderick, John,Corbett, Ronald L.,Duan, James J.-W.,Liu, Rui-Qin,Covington, Maryanne B.,Newton, Robert C.,Trzaskos, James M.,Magolda, Ronald L.,Wexler, Ruth R.,Decicco, Carl P.
, p. 4293 - 4297 (2007/10/03)
Rational design based on the broad spectrum MMP inhibitor CGS 27023A led to the identification of a novel series of cyclic succinate TACE inhibitors. As a mixture of two enantiomers, the lead compound 17b exhibited potent enzyme activity (IC50=
