863666-23-3Relevant articles and documents
Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors
Lu, Qiang,Wang, Da-Sheng,Chen, Chang-Shi,Hu, Yuan-Dong,Chen, Ching-Shih
, p. 5530 - 5535 (2007/10/03)
Previously, we developed a strategy to develop a novel class of histone deacetylase (HDAC) inhibitors by tethering short-chain fatty acids with Zn 2+-chelating motifs, which led to N-hydroxy-4-(4-phenylbutyryl-amino) benzamide (HTPB), a hydroxa