863676-23-7

Basic information

• Product Name: 2-chloro-6-(bromomethyl)benzonitrile
• Synonyms: 2-chloro-6-(bromomethyl)benzonitrile
• CAS NO: 863676-23-7
• Molecular Weight: 230.491
• Mol File: 863676-23-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-(bromomethyl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-(bromomethyl)benzonitrile(863676-23-7)
• EPA Substance Registry System: 2-chloro-6-(bromomethyl)benzonitrile(863676-23-7)

Safety Data

• Hazardous Substances Data: 863676-23-7(Hazardous Substances Data)

Upstream product

• 6575-09-3 2-chloro-6-methyl-benzonitrile 

Downstream Products

• 1426933-73-4 5-chloro-6-trifluoromethyl-7-bromo-4-amino-1H-2,3-benzoxazine 
• 1379331-79-9 2-(bromomethyl)-6-chlorobenzaldehyde 
• 1418202-48-8 5-chloro 2-phenyl-1,2-dihydrophthalazine 
• 1417917-21-5 2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-yl]-2-oxo-pyrrolidin-1-ylmethyl}-benzonitrile 
• 1276041-94-1 2-benzyl-6-chlorobenzonitrile 
• 1276042-12-6 (2-benzoyl-6-chlorophenyl)(p-tolyl)methanone 
• 77532-86-6 2-chloro-6-formylbenzonitrile 
• 1147093-49-9 2-(2-aminoethylsulfanylmethyl)-6-chloro-benzonitrile 
• 145303-65-7 3-[N-(2-cyano-6-chlorobenzyl)-5-indolyl]methyl-5,7-dimethyl-2-ethyl-3H-imidazo[4,5-b]pyridine 

Relevant articles and documents

COMPOUNDS

A compound of formula (I), or a pharmaceutical salt thereof.

4 - PIPERIDINYL COMPOUNDS FOR USE AS TANKYRASE INHIBITORS

The present invention provides for compounds of formula (I).The present invention also provides for pharmaceutical compositions and combinations comprising a compound of formula (I) as well as for the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which include, but are not limited to, cancer.

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere via N-H imines as an intramolecular directing group

Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.