86383-39-3

Basic information

• Product Name: 1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-
• Synonyms: hydroxy-2' dimethoxy-3,4 dihydrochalcone;1-Propanone,3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)
• CAS NO: 86383-39-3
• Molecular Formula: C17H18O4
• Molecular Weight: 286.328
• Mol File: 86383-39-3.mol
• Article Data: 5

Chemical Properties

• Melting Point: 92 °C(Solv: ethanol (64-17-5))
• Boiling Point: 440.5±40.0 °C(Predicted)
• Density: 1.170±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-(86383-39-3)
• EPA Substance Registry System: 1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-(86383-39-3)

Safety Data

• Hazardous Substances Data: 86383-39-3(Hazardous Substances Data)

Usage

Description

1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)-, also known as dTAG-7 (D710015), is an organic compound that serves as an intermediate in the synthesis of degradation tags. It has been tested for its efficiency in depleting FKBP12F36V-MELK(sg3R) and has shown significant degradation within 4 hours.

Uses

Used in Cancer Research:
1-Propanone, 3-(3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)is used as a degradation tag in the study of cancer research. It has been found to effectively deplete FKBP12F36V-MELK(sg3R), a protein involved in cancer cell proliferation and survival, making it a promising candidate for further research and potential therapeutic applications in cancer treatment.

Upstream product

• 19152-36-4 (E)-2'-hydroxy-3,4-dimethoxychalcone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 79140-20-8 2'-hydroxy-3,4-dimethoxychalcone 
• 118-93-4 o-hydroxyacetophenone 
• 93-03-8 (3,4-dimethoxyphenyl)methanol 

Downstream Products

• 84289-41-8 3',4'-dimethoxy-3-benzyl-4-chromanone 
• 6344-21-4 3',4'-dimethoxyflavanone 
• 4143-62-8 3',4'-dimethoxyflavone 
• 89367-09-9 3’,4’-dimethoxyhomoisoflavone 
• 875467-89-3 (+/-)-3-(3',4'-dimethoxybenzyl)-3-hydroxymethyl-2,3-dihydro-4H-1-benzopyran-4-one 

Relevant articles and documents

Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives

A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell

Candida rugosa lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(H)-ones

Candida rugosa lipase, catalyzed enantioselective acetylation reactions have been performed on novel (±)-3-arylmethyl-3-hydroxymethyl-2,3- dihydrobenzopyran-4-ones in diisopropyl ether. The Candida rugosa lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds 5a-g, the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (ee) values are determined by 1H NMR spectral analysis of their O-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of 5c.

Synthesis and angioprotective, antiallergic and antihistaminic activities of 3-benzyl-chromones (homoisoflavones)

Various 3-benzyl-chromones were prepared and their angioprotective antiallergic and antihistaminic activities were studied. - 3-benzyl-chromones / antiallergic / antihistaminic / angioprotective