863912-74-7

Basic information

• Product Name: N-(4-fluorobenzenesulfonyl)-α-dehydrovaline
• Synonyms: N-(4-fluorobenzenesulfonyl)-α-dehydrovaline
• CAS NO: 863912-74-7
• Molecular Weight: 273.285
• Mol File: 863912-74-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-fluorobenzenesulfonyl)-α-dehydrovaline(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-fluorobenzenesulfonyl)-α-dehydrovaline(863912-74-7)
• EPA Substance Registry System: N-(4-fluorobenzenesulfonyl)-α-dehydrovaline(863912-74-7)

Safety Data

• Hazardous Substances Data: 863912-74-7(Hazardous Substances Data)

Upstream product

• 20201-24-5 ethyl 3-methyl-2-oxobutanoate 
• 759-05-7 3-methyl-2-ketobutanoic acid 
• 402-46-0 4-fluorophenylsulphonamide 

Downstream Products

• 190275-60-6 N-(4-fluorophenylsulfonyl)-D-valine 

Relevant articles and documents

Asymmetric hydrogenation of N-sulfonylated-α-dehydroamino acids: Toward the synthesis of an anthrax lethal factor inhibitor

(Chemical Equation Presented) A novel and highly enantioselective Ru-catalyzed hydrogenation of N-sulfonylated-α-dehydroamino acids has been discovered and demonstrated in the synthesis of an anthrax lethal factor inhibitor (LFI). Herein, this methodology is used to prepare N-sulfonylated amino acids in up to 98% ee. This unprecedented hydrogenation uses a chiral Ru catalyst rather than Rh as typical for acylated dehydroamino acids and esters, and this work reports the first asymmetric hydrogenation of a tetrasubstituted dehydroamino acid derivative using a Ru catalyst.