86408-11-9

Basic information

• Product Name: 3,5-Pyridinedicarboxylic acid, 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester
• CAS NO: 86408-11-9
• Molecular Formula: C17H17ClFNO4
• Molecular Weight: 353.778
• Mol File: 86408-11-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,5-Pyridinedicarboxylic acid, 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Pyridinedicarboxylic acid, 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester(86408-11-9)
• EPA Substance Registry System: 3,5-Pyridinedicarboxylic acid, 4-(2-chloro-6-fluorophenyl)-1,4-dihydro-2,6-dimethyl-, dimethyl ester(86408-11-9)

Safety Data

• Hazardous Substances Data: 86408-11-9(Hazardous Substances Data)

Upstream product

• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 103026-79-5 4-(2-Chloro-6-fluoro-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid dimethyl ester 

Relevant articles and documents

1,4-Dihydropyridine antagonist activities at the calcium channel: A quantitative structure-activity relationship approach

The effect of 46 1,4-dihydropyridine-type calcium channel antagonists on the tonic contractile response of longitudinal muscle strips of guinea pig ileum was determined. 2,6-Dimethyl-3,5-dicarbomethoxy-4-phenyl-1,4-dihydropyridine (13) and 13 ortho-, 15 meta-, and seven para-monosubstituted and 10 polysubstituted aromatic derivatives of 13 were studied. The pharmacological activities of the monosubstituted derivatives were best correlated by eq 10, log 1/C = 0.68π + 2.50σ(m) - 0.47L(meta) - 3.40B1(para) + 11.31, which had a correlation coefficient of 0.89. The full data set was best correlated by eq 11, log 1/C = 0.62π + 1.96σ(m) - 0.44L(meta) - 3.26B1(para) - 1.51L(meta) + 14.23, which had a correlation coefficient of 0.90. Equations of similar form but involving an ortho steric term were found to correlate the radioligand binding data for this class of compounds.