864132-53-6Relevant articles and documents
Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: From the active site to the second phosphotyrosine binding site
Wilson, Douglas P.,Wan, Zhao-Kui,Xu, Wei-Xin,Kirincich, Steven J.,Follows, Bruce C.,Joseph-McCarthy, Diane,Foreman, Kenneth,Moretto, Alessandro,Wu, Junjun,Zhu, Min,Binnun, Eva,Zhang, Yan-Ling,Tam, May,Erbe, David V.,Tobin, James,Xu, Xin,Leung, Louis,Shilling, Adam,Tam, Steve Y.,Mansour, Tarek S.,Lee, Jinbo
, p. 4681 - 4698 (2008/03/13)
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of the insulin and leptin receptor pathways and thus an attractive therapeutic target for diabetes and obesity. Starting with a high micromolar lead compound, structure-based optimization of
