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86422-04-0

86422-04-0

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  • Carbamic acid,(1-methylethyl)-,[5-(3,4-dichlorophenyl)-2,3-dihydro-2-hydroxy-1H-pyrrolizine-6,7-diyl]bis(methylene)ester, (R)- (9CI)

    Cas No: 86422-04-0

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  • Carbamic acid,(1-methylethyl)-,[5-(3,4-dichlorophenyl)-2,3-dihydro-2-hydroxy-1H-pyrrolizine-6,7-diyl]bis(methylene)ester, (R)- (9CI) cas 86422-04-0

    Cas No: 86422-04-0

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86422-04-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 86422-04-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,4,2 and 2 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 86422-04:
(7*8)+(6*6)+(5*4)+(4*2)+(3*2)+(2*0)+(1*4)=130
130 % 10 = 0
So 86422-04-0 is a valid CAS Registry Number.
InChI:InChI=1/C23H29Cl2N3O5/c1-12(2)26-22(30)32-10-16-17(11-33-23(31)27-13(3)4)21(28-9-15(29)8-20(16)28)14-5-6-18(24)19(25)7-14/h5-7,12-13,15,29H,8-11H2,1-4H3,(H,26,30)(H,27,31)/t15-/m1/s1

86422-04-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Carbamic acid, (1-methylethyl)-, [5-(3,4-dichlorophenyl)-2,3-dihydro-2-hydroxy-1H-pyrrolizine-6,7-diyl]bis(methylene) ester, (R)-

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

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More Details:86422-04-0 SDS

86422-04-0Relevant articles and documents

Synthesis, Evaluation of Chemical Reactivity, and Murine Antineoplastic Activity of 2-Hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine Bis(2-propylcarbamate) and 2-Acyloxy Derivatives as Potential Water-Soluble Prodrugs

Anderson, Wayne K.,Chang, Chiung-Pin,McPherson, Howard L.

, p. 1333 - 1338 (2007/10/02)

2-Hydroxy-5-(3,4-dichlorophenyl)-6,7-bis(hydroxymethyl)-2,3-dihydro-1H-pyrrolizine bis(2-propylcarbamate) (11) was prepared in multistep synthesis.The 2-hydroxy group was used to prepare ester prodrugs 14 and 15, and the antineoplastic activities of 11, 14, and 15a were compared to 1 (the 2-deoxy analogue of 11) in murine P388 lymphocytic leukemia and B16 melanocarcinoma.The alcohol 11 showed comparable activity to 1, while 14 was less active and 15a showed very low activity.The hydrolytic rates of 1, 11, 14, 15a and 15b were compared, and it was found that the two carbamate moieties were much more susceptible toward hydrolysis than C-2 esters.The salts 15a and 15b exhibited good water solubility, 3.0 * 10-2 and 3.88 * 10-2 M, respectively

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