864245-38-5

Basic information

• Product Name: 4-Pyrimidinamine, 6-(2-fluoro-4-nitrophenoxy)-
• CAS NO: 864245-38-5
• Molecular Formula: C10H7FN4O3
• Molecular Weight: 250.189
• Mol File: 864245-38-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 4-Pyrimidinamine, 6-(2-fluoro-4-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyrimidinamine, 6-(2-fluoro-4-nitrophenoxy)-(864245-38-5)
• EPA Substance Registry System: 4-Pyrimidinamine, 6-(2-fluoro-4-nitrophenoxy)-(864245-38-5)

Safety Data

• Hazardous Substances Data: 864245-38-5(Hazardous Substances Data)

Upstream product

• 403-19-0 2-fluoro-4-nitrophenol 
• 5305-59-9 4-amino-6-chloropyrimidine 
• 868733-35-1 6-(2-fluoro-4-nitrophenoxy)-N-(4-methoxybenzyl)pyrimidin-4-amine 
• 868733-15-7 4-chloro-6-(2-fluoro-4-nitrophenoxy)pyrimidine 

Downstream Products

• 864245-39-6 Pyrrolidine-1-carboxylic acid [6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl]amide 
• 864245-40-9 pyrrolidine-1-carboxylic acid [6-(4-amino-2-fluorophenoxy)pyrimidin-4-yl]amide 
• 928038-21-5 [6-(2-Fluoro-4-{[1-(4-fluorophenylcarbamoyl)cyclopropanecarbonyl]amino}phenoxy)pyrimidin-4-yl]carbamic acid phenyl ester 
• 928038-20-4 [6-(4-amino-2-fluorophenoxy)pyrimidin-4-yl]carbamic acid phenyl ester 
• 864245-55-6 [6-(2-Fluoro-4-nitrophenoxy)pyrimidin-4-yl]carbamic acid phenyl ester 
• 868733-29-3 6-(N,N-di-tert-butyloxycarbonyl)amino-4-(2-fluoro-4-nitrophenoxy)pyrimidine 
• 864245-45-4 3-[6-(2-Fluoro-4nitrophenoxy)pyrimidin-4-yl]-1,1-dimethylurea 
• 864245-41-0 Morpholine-4-carboxylic acid [6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl]amide 
• 864245-43-2 Piperidine-1-carboxylic acid [6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-yl]amide 

Relevant articles and documents

PYRIDINE OR PYRIMIDINE DERIVATIVE HAVING EXCELLENT CELL GROWTH INHIBITION EFFECT AND EXCELLENT ANTI-TUMOR EFFECT ON CELL STRAIN HAVING AMPLIFICATION OF HGFR GENE

A pyridine or pyrimidine derivative represented by the formula (I) has an excellent HGFR inhibitory activity and exhibits strong cell proliferation inhibitory effect and anti-tumor effect against cancer cell lines with amplified HGFR gene. wherein R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen.

NOVEL PYRIDINE DERIVATIVE AND PYRIMIDINE DERIVATIVE (3)

A compound represented by the following formula, a salt thereof or a hydrate of the foregoing has an excellent hepatocyte growth factor receptor (HGFR) inhibitory activity, and exhibits anti-tumor activity, angiogenesis inhibitory activity and cancer metastasis inhibitory activity. [R1 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; R2 and R3 represent hydrogen; R4, R5, R6, and R7 may be the same or different and each represents hydrogen, halogen, C1-6 alkyl or the like; R8 represents hydrogen or the like; R9 represents a 3- to 10-membered non-aromatic heterocyclic group or the like; n represents an integer of 1 or 2; X represents -CH=, nitrogen or the like.]

Monocyclic heterocycles as kinase inhibitors

The present invention is directed to compounds having the formula and methods for using them for the treatment of cancer.