864277-08-7

Basic information

• Product Name: N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine
• Synonyms: N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine
• CAS NO: 864277-08-7
• Molecular Weight: 554.734
• Mol File: 864277-08-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine(864277-08-7)
• EPA Substance Registry System: N-(3’-(piperidin-1-ylmethyl)-[1,1’-biphenyl]-4-yl)sulfonyl-N’-(5-ethoxycarbonylthiazol-2-yl)piperazine(864277-08-7)

Safety Data

• Hazardous Substances Data: 864277-08-7(Hazardous Substances Data)

Upstream product

• 59507-40-3 1-(3-bromobenzyl)piperidine 
• 864277-04-3 1-(5-ethoxycarbonylthiazol-2-yl)-4-(4-iodophenylsulfonyl)piperazine 
• 859833-21-9 1-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)piperidine 
• 873075-57-1 ethyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)thiazole-5-carboxylate 
• 41731-83-3 ethyl 2-bromo-1,3-thiazole-5-carboxylate 

Downstream Products

• 864277-07-6 C₂₆H₃₀N₄O₄S₂ 

Relevant articles and documents

Synthesis of Biaryls Having a Piperidylmethyl Group Based on Space Integration of Lithiation, Borylation, and Suzuki–Miyaura Coupling

In a flow microreactor, aryllithiums bearing a piperidylmethyl group were generated using nBuLi by precise residence time control and effective temperature control, and then selectively borylated with boronic esters such as 2-isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (BpinOiPr) and trimethyl borate B(OMe)3 by fast mixing. Moreover, the direct integration with Suzuki–Miyaura cross coupling were successfully achieved to obtain nitrogen-containing biaryl compounds. The present method could be applied for the straightforward synthesis of the key intermediate of a bioactive component bearing a piperidylmethyl-biphenyl framework.