864546-06-5

Basic information

• Product Name: 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexanol
• Synonyms: 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexanol
• CAS NO: 864546-06-5
• Molecular Weight: 311.181
• Mol File: 864546-06-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexanol(864546-06-5)
• EPA Substance Registry System: 4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-cyclohexanol(864546-06-5)

Safety Data

• Hazardous Substances Data: 864546-06-5(Hazardous Substances Data)

Upstream product

• 6850-65-3 p-hydroxycyclohexylamine 
• 63744-22-9 6,8-dibromoimidazo[1,2-a]pyrazine 

Relevant articles and documents

Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells

Co-crystallisation of the imidazo[1,2-a]pyrazine derivative 15 (3-chloro-N-(4-morpholinophenyl)-6-(pyridin-3-yl)imidazo[1,2-a]pyrazin-8-amine) with Aurora-A provided an insight into the interactions of this class of compound with Aurora kinases. This led to the design and synthesis of potent Aurora-A inhibitors demonstrating up to 70-fold selectivity in cell-based Aurora kinase pharmacodynamic biomarker assays.