864684-98-0

Basic information

• Product Name: 2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 864684-98-0
• Molecular Formula: C14H16N2O2S
• Molecular Weight: 276.35404
• Mol File: 864684-98-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 420.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.180±0.06 g/cm3(Predicted)
• PKA: 3.05±0.10(Predicted)
• CAS DataBase Reference: 2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(864684-98-0)
• EPA Substance Registry System: 2-(2-ETHYL-PYRIDIN-4-YL)-4-METHYL-THIAZOLE-5-CARBOXYLIC ACID ETHYL ESTER(864684-98-0)

Safety Data

• Hazardous Substances Data: 864684-98-0(Hazardous Substances Data)

Usage

Structure

Ethyl ester derivative of thiazole carboxylic acid with a pyridinyl group attached

Pharmacological properties

Diverse, making it a valuable building block for the synthesis of potential drug candidates

Potential uses

Treatment of various diseases, including cancer, cardiovascular disorders, and neurological disorders

Role in drug discovery

Valuable tool for pharmaceutical research and development

Upstream product

• 536-33-4 ethionamide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 84911-18-2 ethyl 2-bromoacetoacetate 

Downstream Products

• 1384111-24-3 2-(2-ethylpyridin-4-yl)-4-methyl-N-phenylthiazole-5-carboxamide 
• 1384111-18-5 C₂₂H₂₅N₃O₂S 
• 1384111-16-3 C₂₁H₂₃N₃O₂S 
• 1384111-15-2 C₂₀H₂₁N₃O₂S 
• 1384111-23-2 2-(2-ethylpyridin-4-yl)-N-(2-methoxyphenyl)-4-methylthiazole-5-carboxamide 
• 1384110-97-7 N-(4-bromophenyl)-2-(2-ethylpyridin-4-yl)-4-methylthiazole-5-carboxamide 

Relevant articles and documents

Synthesis, antimicrobial screening, and docking study of new 2-(2-ethylpyridin-4-yl)-4-methyl-N-phenylthiazole-5-carboxamide derivatives

A series of new 2-(2-ethylpyridin-4-yl)-4-methyl-N-phenylthiazole-5-carboxamide derivatives (5a-l) were synthesized and evaluated for their in vitro antimicrobial activities. Among the screened compounds, 5b, 5d, 5e, 5f, and 5j have shown promising antimicrobial activities against both bacterial and fungal pathogens. A molecular docking study was conducted to know the probable mode of action of synthesized derivatives for antimicrobial activity. The active compounds have shown excellent binding affinity toward DNA gyrase and lumazine synthase enzymes. The physicochemical properties of the synthesized thiazole-carboxamide derivatives were calculated. It has displayed the potential to be a reasonable oral bioavailability drug as determined by Lipinski's rule.

Aromatic heterocyclic small molecule organic compounds and derivatives, preparation method and medical use

The invention discloses heterocyclic aromatic micromolecule organic compounds as shown in the structural formula (I) and derivatives thereof, or hydrates or pharmaceutically acceptable salts, and a preparation method of the corresponding compounds; the invention also discloses an application of the compounds and pharmaceutical compositions containing the compounds to the treatment of various metabolic syndrome-related diseases. The heterocyclic aromatic micromolecule organic compounds of the invention have excellent treatment effect on metabolic syndromes; experiment results show that the compounds may promote secretion of endogenous GLP-1, and are applicable to the preparation of anti-diabetic and fat-reducing candidate medicaments. Aiming at technical problems of easy degradation and short half life of current medicaments for treating diabetes, the invention provides novel, high-efficient micromolecule compounds for promoting secretion of endogenous GLP-1, and the compounds are applicable to the treatment of metabolic syndrome-related diseases such as diabetes, obesity and the like.