864847-17-6Relevant articles and documents
Copper catalyzed arylation with boronic acids for the synthesis of N 1-aryl purine nucleosides
Strouse, J. Jacob,Jeselnik, Marjan,Tapaha, Frederick,Jonsson, Colleen B.,Parker, William B.,Arterburn, Jeffrey B.
, p. 5699 - 5702 (2005)
The synthesis of a series of N1-aryl inosine and guanosine derivatives is described. The procedure for chemoselective N1- arylation involves the mild oxidative copper(II) mediated coupling with boronic acids. This approach provides access to substituted N1-aryl purines with interesting structural characteristics and novel scaffolds for drug discovery.