86492-48-0

Basic information

• Product Name: ((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-dimethyl-ammonium; chloride
• CAS NO: 86492-48-0
• Molecular Weight: 493
• Mol File: 86492-48-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-dimethyl-ammonium; chloride(CAS DataBase Reference)
• NIST Chemistry Reference: ((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-dimethyl-ammonium; chloride(86492-48-0)
• EPA Substance Registry System: ((2R,3R,4S,5S,6S)-6-Carboxy-3,4,5-trihydroxy-tetrahydro-pyran-2-yl)-[3-(10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-dimethyl-ammonium; chloride(86492-48-0)

Safety Data

• Hazardous Substances Data: 86492-48-0(Hazardous Substances Data)

Upstream product

• 50-49-7 impramine 
• 21085-72-3 1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester 

Relevant articles and documents

Synthesis and characterization of quaternary ammonium-linked glucuronide metabolites of drugs with an aliphatic tertiary amine group

A synthetic approach was developed to make the quaternary ammonium-linked glucuronide metabolites of compounds with an aliphatic tertiary amine group. The key step involved quaternization of the compound with methyl (2,3,4-tri- O-acetyl-α-D-glucopyranosyl bromide)uronate and sodium bicarbonate in a two- phase system of water and an organic solvent. The synthetic approach successfully yielded quaternary ammonium-linked glucuronides of 20 drugs and two of their phase I metabolites. The drugs were from various pharmacological classes: H1 antihistamines, antipsychotic agents, and tricyclic antidepressants. Physical data such as HPLC retention times, and diagnostic fast-atom bombardment mass spectra and 1H NMR spectra were obtained. These should aid in the characterization of compounds in samples isolated from biological media.