864960-96-3

Basic information

• Product Name: 3-(4-Fluoro-3-Methoxyphenyl)propionic acid, 96%
• Synonyms: 3-(4-Fluoro-3-Methoxyphenyl)propionic acid, 96%;3-(4-fluoro-3-methoxyphenyl)propanoic acid;4-Fluoro-3-methoxy-benzenepropanoic acid;Benzenepropanoic acid, 4-fluoro-3-methoxy-
• CAS NO: 864960-96-3
• Molecular Formula: C₁₀H₁₁FO₃
• Molecular Weight: 198.1909432
• Mol File: 864960-96-3.mol
• Article Data: 9

Chemical Properties

• Melting Point: 90-94℃
• Appearance: /
• CAS DataBase Reference: 3-(4-Fluoro-3-Methoxyphenyl)propionic acid, 96%(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Fluoro-3-Methoxyphenyl)propionic acid, 96%(864960-96-3)
• EPA Substance Registry System: 3-(4-Fluoro-3-Methoxyphenyl)propionic acid, 96%(864960-96-3)

Safety Data

• Hazardous Substances Data: 864960-96-3(Hazardous Substances Data)

Usage

Uses

3-(4-Fluoro-3-methoxyphenyl)propanoic acid is used as a reactant in the preparation of [(heterocyclylmethoxy)aryl]alkanoic acid derivatives as GPR120 receptor agonists useful in the treatment of metabolic disorders.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 128495-46-5 4-fluoro-3-methoxybenzaldehyde 
• 864960-95-2 3-(4-fluoro-3-methoxyphenyl)-2-propenoic acid ethyl ester 
• 1036391-73-7 ethyl 3-(4-fluoro-3-methoxyphenyl)propanoate 
• 630424-79-2 (E)-3-(4-fluoro-3-methoxyphenyl) acrylic acid 

Downstream Products

• 864960-94-1 [2-(4-fluoro-3-methoxyphenyl)ethyl]carbamic acid t-butyl ester 
• 1224104-16-8 C₁₄H₁₇FO₃ 
• 1224104-17-9 ethyl 3-(3,5-difluoro-4-hydroxyphenyl)-2-ethoxypropanoate 
• 864960-98-5 [2-(4-fluoro-3-methoxyphenyl)ethyl]methylcarbamic acid t-butyl ester 
• 864960-99-6 [2-(4-Fluoro-3-methoxyphenyl)ethyl]methylamine hydrochloride 
• 154550-93-3 2-(4-fluoro-3-methoxyphenyl)ethan-1-amine hydrochloride 

Relevant articles and documents

Design, synthesis, and characterization of oxadiazolopyrazine analogs with application as anticancer agents

Here, we describe the synthesis and evaluation of a class of cell-permeable indeno-oxadiazolopyrazine analogs as the anticancer agents. A new and facile approach to the synthesis of substituted analogs of indeno-oxadiazolopyrazine is illustrated. We find that the designed indeno-oxadiazolopyrazines, 3, 4, 10, 11, 15, and 16, act as potent anticancer agents compared to camptothecin, topoisomerase I inhibitor. These observations suggest that the electron-donating group (methoxy) at the C-5, C-6, and C-8 positions or electron-withdrawing group (fluoro) at the C-6 and C-7 positions on the A ring of indeno-oxadiazolopyrazines is required for antiproliferative activities against MDA-MB-231, BT549, and MCF7 cell lines.

SUBSTITUTED 2,2'-BIPYRIMIDINYL COMPOUNDS, ANALOGUES THEREOF, AND METHODS USING SAME

The present invention includes substituted 2,2'-bipyrimidinyl compounds, analogues thereof, and compositions comprising the same, which can be used to treat and/or prevent hepatitis B virus (HBV) and/or hepatitis B virus (HBV)-hepatitis D virus (HDV) infection in a patient.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.