864970-16-1

Basic information

• Product Name: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-propyl-
• CAS NO: 864970-16-1
• Molecular Formula: C17H18N4O3
• Molecular Weight: 326.355
• Mol File: 864970-16-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-propyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-propyl-(864970-16-1)
• EPA Substance Registry System: Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 4-[(3-hydroxy-4-methylphenyl)amino]-5-propyl-(864970-16-1)

Safety Data

• Hazardous Substances Data: 864970-16-1(Hazardous Substances Data)

Upstream product

• 109578-37-2 ethyl 4-propyl-1H-pyrrole-3-carboxylate 
• 27829-72-7 ethyl (E)-hex-2-enoate 
• 310436-48-7 5-Propylpyrrolo[2,1-f][1,2,4]triazin-4(3H)-one-6-carboxylic Acid Ethyl Ester 
• 310444-19-0 4-(3-hydroxy-4-methyl-phenylamino)-5-propyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid ethyl ester 

Relevant articles and documents

Synthesis and SAR of 4-(3-hydroxyphenylamino)pyrrolo[2,1-f][1,2,4]triazine based VEGFR-2 kinase inhibitors

A versatile synthesis of the suitably functionalized pyrrolo[2,1-f][1,2,4] triazine nucleus is described. SAR at the C-5 and C-6 positions of the 4-(3-hydroxy-4-methylphenylamino)pyrrolo[2,1-f][1,2,4]triazine template led to compounds with good in vitro potency against VEGFR-2 kinase. Glucuronidation of the phenol group is mitigated by incorporation of a basic amino group on the C-6 side chain of the pyrrolotriazine nucleus.