86499-23-2

Basic information

• Product Name: 3-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
• Synonyms: 3-chloro-1,3,4,5-tetrahydro-2h-1-benzazepin-2-one;3-Chlorine-2,3,4,5-tetrahydro-2H-1-benzazepin-2-one;3-CHLORO-2,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE;3-chloro-2,3,4,5-tetrahydro-2H-1-benzazepine-2-one;3-CHLORO-1,3,4,5--TETRAHYDRO-1H-1-BENZAZEPIN-2-ONE;IHT-PI CBC;3-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one;3-Chloro-4,5-dihydro-1H-benzo[b]azepin-2(3H)-one
• CAS NO: 86499-23-2
• Molecular Formula: C₁₀H₁₀ClNO
• Molecular Weight: 195.65
• Mol File: 86499-23-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 164-167 °C
• Boiling Point: 379.5 °C at 760 mmHg
• Flash Point: 183.3 °C
• Appearance: /
• Density: 1.27 g/cm³
• Vapor Pressure: 5.84E-06mmHg at 25°C
• Refractive Index: 1.589
• PKA: 13.59±0.40(Predicted)
• CAS DataBase Reference: 3-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(86499-23-2)
• EPA Substance Registry System: 3-Chloro-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one(86499-23-2)

Safety Data

• Hazardous Substances Data: 86499-23-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10ClNO/c11-8-6-5-7-3-1-2-4-9(7)12-10(8)13/h1-4,8H,5-6H2,(H,12,13)

Upstream product

• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 
• 4424-80-0 2,3,4,5-tetrahydro-1H-1-benzo[b]azepin-2-one 
• 86499-22-1 3,3-dichloro-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one 

Downstream Products

• 97278-68-7 3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine 
• 1093980-71-2 (R)-3-{4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,2,3-triazol-1-yl}-1,3,4,5-tetrahydro-1-benzazepin-2-one 
• 1093975-42-8 (S)-3-{4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]-1,2,3-triazol-1-yl}-1,3,4,5-tetrahydro-1-benzazepin-2-one 
• 86499-52-7 (S)-3-amino-1-ethoxycarbonylmethyl-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-one 
• 86541-77-7 (3S)-1-(carboxymethyl)-<<(1S)-1-(ethoxycarbonyl)-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one hydrochloride 
• 86541-78-8 (3S)-1-(carboxymethyl)-<<(1S)-1-carboxy-3-phenylpropyl>amino>-2,3,4,5-tetrahydro-1H-<1>benzazepin-2-one 
• 86541-74-4 benazepril hydrochloride 
• 239097-60-0 3-carboxy-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 239097-83-7 1-N-(3-(N'-(3-isopropylureido))benzyl)-3-(methoxycarbonyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 239097-82-6 3-(aminomethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 239097-84-8 3-(hydroxymethyl)-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 239097-58-6 3-cyano-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 239097-81-5 3-(phenylcarbamoyloxy)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 
• 211761-80-7 3-chloro-1-N-(3-(N'-(3-isopropylureido))benzyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one 

Relevant articles and documents

Discovery of novel triazolobenzazepinones as γ-secretase modulators with central Aβ42 lowering in rodents and rhesus monkeys

Abstract Synthesis and SAR studies of novel triazolobenzazepinones as gamma secretase modulators (GSMs) are presented in this communication. Starting from our azepinone leads, optimization studies toward improving central lowering of Aβ42 led to the discovery of novel benzo-fused azepinones. Several benzazepinones were profiled in vivo and found to lower brain Aβ42 levels in Sprague Dawley rats and transgenic APP-YAC mice in a dose-dependent manner after a single oral dose. Compound 34 was further progressed into a pilot study in our cisterna-magna-ported rhesus monkey model, where we observed robust lowering of CSF Aβ42 levels.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.

Mild Hydrogen-Transfer Reductions Using Sodium Hypophosphite

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