86499-39-0

Basic information

• Product Name: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)
• Synonyms: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI);alpha-[(2,3,4,5-Tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]benzenebutanoic acid ethyl ester
• CAS NO: 86499-39-0
• Molecular Formula: C22H26N2O3
• Molecular Weight: 366.45
• Mol File: 86499-39-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.17
• CAS DataBase Reference: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)(86499-39-0)
• EPA Substance Registry System: Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI)(86499-39-0)

Safety Data

• Hazardous Substances Data: 86499-39-0(Hazardous Substances Data)

Usage

General Description

Benzenebutanoicacid,[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-, ethylester, (R*,S*)-(9CI) is a chemical compound with the molecular formula C26H32N2O4. It is an ethyl ester derivative of benzenebutanoic acid with a substituted 1-benzazepin-3-yl amino group. Benzenebutanoicacid,-[(2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl)amino]-,ethylester,(R*,S*)-(9CI) is a chiral molecule with two stereocenters, denoted as (R*,S*), and it is classified in the chemical database under the name (9CI). It may have pharmaceutical applications due to its structural features, but its specific uses and properties have not been widely reported. Further research is necessary to fully understand the potential uses and effects of this compound.

Upstream product

• 74-96-4 ethyl bromide 
• 127-19-5 N,N-dimethyl acetamide 
• 75-03-6 ethyl iodide 
• 656830-87-4 (R)-2,4-Dihydroxy-4-(2-nitro-phenyl)-butyric acid ethyl ester 
• 608148-58-9 (2R)-2-hydroxy-4-(2-nitrophenyl)-4-oxobutyric acid ethyl ester 
• 608148-60-3 (3R)-3-hydroxy-1,3,4,5-tetrahydrobenzo[b]azepin-2-one 
• 178114-28-8 4-(2-nitrophenyl)-2,4-dioxobutanoic acid ethyl ester 
• 46460-23-5 ethyl 2-amino-4-phenyl-(2S)-butyrate 
• 608148-63-6 4-nitrobenzenesulfonic acid (3R)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester 
• 577-59-3 2-acetylnitrobenzene 
• 942049-14-1 trans-4-(2-nitrophenyl)-4-oxo-but-2-enoic acid methyl ester 

Relevant articles and documents

Formal synthesis of the ACE inhibitor benazepril·HCl via an asymmetric aza-Michael reaction

A formal enantioselective synthesis of benazepril·HCl (4), an antihypertensive drug, is reported. Our synthesis employed an asymmetric aza-Michael addition of L-homophenylalanine ethyl ester (LHPE, 1) to 4-(2-nitrophenyl)-4-oxo-but-2-enoic acid methyl est

Kinetic resolution of a intermediate useful in the production of benazepril and analogues thereof

The present invention provides an efficient synthetic process for making benazepril and analogues thereof by having an intermediate compound undergo epimerization and kinetic resolution.

3-Amino-[1]-benzazepin-2-one-1-alkanoic acids

Variously substituted 1-carboxymethyl-3-(carboxymethylamino)-2,3,4,5-tetrahydro-1H-[1]benzazepin-2-ones and functional derivatives are angiotensin converting enzyme inhibitors and are useful as antihypertensive agents. Synthesis of, compositions and methods of treatment utilizing such compounds are included.