865080-01-9

Basic information

• Product Name: (2'R,3'S,4'R,5'R)-6-Bromo-1'-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide
• Synonyms: (2'R,3'S,4'R,5'R)-6-Bromo-1'-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide
• CAS NO: 865080-01-9
• Molecular Weight: 666.658
• Mol File: 865080-01-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2'R,3'S,4'R,5'R)-6-Bromo-1'-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2'R,3'S,4'R,5'R)-6-Bromo-1'-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide(865080-01-9)
• EPA Substance Registry System: (2'R,3'S,4'R,5'R)-6-Bromo-1'-((1R,2S)-2-hydroxy-1,2-diphenyl-ethyl)-2'-isobutyl-2-oxo-4'-phenyl-1,2-dihydro-spiro[indole-3,3'-pyrrolidine]-5'-carboxylic acid dimethylamide(865080-01-9)

Safety Data

• Hazardous Substances Data: 865080-01-9(Hazardous Substances Data)

Upstream product

• 124-40-3 dimethyl amine 
• 865079-94-3 6-Bromo-3-[1-phenyl-meth-(E)-ylidene]-1,3-dihydro-indol-2-one 
• 100-52-7 benzaldehyde 
• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 

Relevant articles and documents

Synthesis of spirooxindoles via asymmetric 1,3-dipolar cycloaddition

An efficient method was developed for the asymmetric synthesis of 2′-alkyl-4′aryl-1H-spiro[indole-3,3′-pyrrolidin]-2-ones, which are potential inhibitors of the p53-MDM2 interaction. Our X-ray crystallographic analysis revealed that this 1,3-dipolar cycloaddition proceeds with high stereoselectivity but differently from previously published results.