86536-92-7

Basic information

• Product Name: Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester
• Synonyms: 6-(tert-butoxycarbonylamino)hexyl 4-methylbenzenesulfonate;6-(p-toluenesulfonyloxy)-N-(tert-butoxycarbonyl)aminohexane;6-((tert-butoxycarbonyl)amino)hexyl p-toluenesulfonate;6-(p-toluenesulfonyloxy)-N-(tert-butoxycarbonyl)hexylamine;6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate;Toluene-4-sulfonic acid 6-tert-butoxycarbonylamino-hexyl ester;N-tert-butyloxycarbonyl-6-aminohexyl-4-toluenesulfonate
• CAS NO: 86536-92-7
• Molecular Formula: C18H29NO5S
• Molecular Weight: 371.498
• Mol File: 86536-92-7.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester(86536-92-7)
• EPA Substance Registry System: Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester(86536-92-7)

Safety Data

• Hazardous Substances Data: 86536-92-7(Hazardous Substances Data)

Usage

Description

Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester is a chemical compound with a six-carbon linker containing a tosyl group and a Boc-protected amine group. The tosyl group serves as an excellent leaving group for nucleophilic substitution reactions, while the Boc group can be deprotected under mild acidic conditions to form a free amine.

Uses

Used in Pharmaceutical Industry:
Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester is used as an intermediate in the synthesis of pharmaceutical compounds. Its unique structure allows for the formation of various functional groups, making it a versatile building block in the development of new drugs.
Used in Chemical Synthesis:
In the field of chemical synthesis, Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester is used as a reagent for the preparation of various organic compounds. Its ability to undergo nucleophilic substitution reactions and the ease of Boc deprotection make it a valuable component in the synthesis of complex molecules.
Used in Research and Development:
Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester is also utilized in research and development settings to study the properties and reactions of various chemical compounds. Its unique structure and reactivity make it an interesting subject for scientific investigation and potential applications in various fields.

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 19008-71-0 8-aminooctan-1-ol 
• 144183-31-3 N-(8-hydroxyoctyl)carbamic acid tert-butyl ester 
• 98-59-9 p-toluenesulfonyl chloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1070-19-5 N-(tert-butyloxycarbonyl) azide 
• 75937-12-1 6-(Boc-amino)-1-hexanol 

Downstream Products

• 172846-36-5 (6-iodohexyl)-carbamic acid 1,1-dimethylethyl ester 
• 173436-02-7 (7-hydroxyheptyl)carbamic acid tert-butyl ester 
• 1427049-54-4 C₁₉H₂₉NO₅ 
• 1427049-59-9 C₆₁H₇₈N₆O₁₃ 

Relevant articles and documents

A Novel Synthesis of Tri-, Di-, and Mono-9-acridinyl Derivatives of Tetra-, Tri-, and Di-amines

Mono-9-acridinyl derivatives, potential polyintercalating hetero-di-9-acridinylamines, and homo- or hetero-tri-9-acridinylamines were prepared from partially Boc-protected polyamines.

TARGET PROTEIN EED DEGRADATION-INDUCING DEGRADUCER, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES RELATED TO EED, EZH2, OR PRC2, COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a target protein degradation-inducing Degraducer, a preparation method thereof, and a pharmaceutical composition for preventing or treating diseases related to EED, EZH2, or PRC2 comprising same as an active ingredient. A novel compound represented by formula 1, according to the present invention is a Degraducer compound that induces degradation of a target protein, i.e., embryonic ectoderm development (EED) or polycomb repressive complex 2 (PRC2), utilizing cereblon E3 ubiquitin ligase, von Hippel-Lindau tumor suppressor (VHL) E3 ubiquitin ligase, mouse double minute 2 homolog (MDM2) E3 ubiquitin ligase, and cellular inhibitor of apoptosis protein 1 (cIAP) E3 ubiquitin ligase, wherein the compound has an aspect of remarkably achieving target protein degradation-inducing activity through a ubiquitin proteasome system (UPS), and therefore there is a useful effect in that it is possible to provide a pharmaceutical composition for preventing or treating diseases or conditions related to a target protein, and a functional health food composition for preventing or improving same, comprising said compound as an active ingredient.

ISOTHIOCYANATE AND ISOSELENOCYANATE COMPOUNDS

The present invention relates to a new family of isothiocyanates and isoselenocyanates compounds suitable to be used as theranostic agents.