865364-20-1

Basic information

• Product Name: (4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
• Synonyms: (4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine
• CAS NO: 865364-20-1
• Molecular Weight: 262.674
• Mol File: 865364-20-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine(865364-20-1)
• EPA Substance Registry System: (4-chloro-2-fluoro-phenyl)-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amine(865364-20-1)

Safety Data

• Hazardous Substances Data: 865364-20-1(Hazardous Substances Data)

Upstream product

• 3680-71-5 7-deazahypoxanthine 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 3680-69-1 4-chloro-1H-pyrrolo[2,3-d]pyrimidine 

Downstream Products

• 865364-29-0 4-(4-chloro-2-fluoro-phenylamino)-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one 

Relevant articles and documents

Rational design of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones as a novel class of inhibitors of epidermal growth factor receptor (EGF-R) and Her2(p185(erbB)) tyrosine kinases.

A novel class of 4,5-disubstituted-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-ones has been discovered as potent and selective inhibitors of the EGF-R tyrosine kinase family. These compounds selectively inhibit EGF-R kinase activity at low nanomolar concentration and tyrosine autophosphorylation in cells expressing EGF-R or Her2 (p185(erbB)). Structure-activity relationships (SARs) for this class of compounds are presented.