865434-72-6

Basic information

• Product Name: 6-(hydroxymethyl)-9-(2,3,5-tri-O-(p-toluolyl)-β-D-ribofuranosyl)purine
• Synonyms: 6-(hydroxymethyl)-9-(2,3,5-tri-O-(p-toluolyl)-β-D-ribofuranosyl)purine
• CAS NO: 865434-72-6
• Molecular Weight: 636.661
• Mol File: 865434-72-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 6-(hydroxymethyl)-9-(2,3,5-tri-O-(p-toluolyl)-β-D-ribofuranosyl)purine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(hydroxymethyl)-9-(2,3,5-tri-O-(p-toluolyl)-β-D-ribofuranosyl)purine(865434-72-6)
• EPA Substance Registry System: 6-(hydroxymethyl)-9-(2,3,5-tri-O-(p-toluolyl)-β-D-ribofuranosyl)purine(865434-72-6)

Safety Data

• Hazardous Substances Data: 865434-72-6(Hazardous Substances Data)

Upstream product

• 865434-71-5 6-(acetyloxymethyl)-9-(2,3,5-tri-O-(p-toluolyl)-β-D-ribofuranosyl)purine 
• 756494-14-1 6-chloro-9-[2,3,5-tri-O-(4-methylbenzoyl)-β-D-ribofuranosyl]purine 
• 906482-33-5 6-formyl-9-(2,3,5-tri-O-p-toluoyl-β-D-ribofuranosyl)purine 
• 593-51-1 methylamine hydrochloride 
• 10024-89-2 morpholin hydrochloride 
• 3287-99-8 benzylamine hydrochloride 
• 4998-76-9 cyclohexylamine hydrochloride 

Downstream Products

• 865434-74-8 6-(fluoromethyl)-9-(2,3,5-tri-O-(p-toluoyl)-β-D-ribofuranosyl)purine 
• 865434-79-3 6-(methanesulfonyloxymethyl)-9-(2,3,5-tri-O-(p-toluoyl)-β-D-ribofuranosyl)purine 
• 906482-33-5 6-formyl-9-(2,3,5-tri-O-p-toluoyl-β-D-ribofuranosyl)purine 
• 906482-36-8 6-(difluoromethyl)-9-(2,3,5-tri-O-p-toluoyl-β-D-ribofuranosyl)purine 
• 865434-83-9 6-(iodomethyl)-9-(2,3,5-tri-O-(p-toluoyl)-β-D-ribofuranosyl)purine 

Relevant articles and documents

Synthesis, cytostatic and anti-HCV activity of 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides

An efficient and facile synthesis of a large series of diverse 6-(N-substituted aminomethyl)-, 6-(O-substituted hydroxymethyl)- and 6-(S-substituted sulfanylmethyl)purine nucleosides (55 examples of both ribo- and 2′-deoxyribonucleosides), aimed at identifying novel homologues of natural nucleosides, was developed. The key transformation involved nucleophilic substitutions of Tol-protected 6-(mesyloxymethyl)purine nucleosides by primary or secondary amines, alcoholates or thiolates. While the 2′-deoxyribonucleosides were inactive, the ribonucleosides exerted considerable cytostatic effects and some anti-HCV activity with low selectivity.