865716-50-3

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[5-hydroxy-2-(2-propenyloxy)phenyl]-
• CAS NO: 865716-50-3
• Molecular Formula: C17H13NO4
• Molecular Weight: 295.295
• Mol File: 865716-50-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[5-hydroxy-2-(2-propenyloxy)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[5-hydroxy-2-(2-propenyloxy)phenyl]-(865716-50-3)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[5-hydroxy-2-(2-propenyloxy)phenyl]-(865716-50-3)

Safety Data

• Hazardous Substances Data: 865716-50-3(Hazardous Substances Data)

Upstream product

• 865716-36-5 2-(2-(allyloxy)-5-{[tert-butyl(diphenyl)silyl]oxy}phenyl)-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors

A variety of macrocyclic urea compounds were prepared as potent Chk1 inhibitors by modifying the C5 position of the benzene ring of the macrocyclic urea with ether moieties, aliphatic carbon chains, amide and halides. Enzymatic activity less than 20 nM was observed in 29 of 40 compounds. Compounds 14, 46d, and 48j provided the best overall results in the cellular assays as they abrogated doxorubicin-induced cell cycle arrest (IC50 = 3.31, 3.08, and 3.13 μM) and enhanced doxorubicin cytotoxicity (IC50 = 0.54, 1.27, and 0.96 μM) while displaying no single agent activity, respectively.