Cas 865980-39-8,(5'-cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid benzyl ester

865980-39-8

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Basic information

Product Name: (5'-cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid benzyl ester
Synonyms: (5'-cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid benzyl ester
CAS NO:865980-39-8
Molecular Formula:
Molecular Weight: 350.42
EINECS: N/A
Product Categories: N/A
Mol File: 865980-39-8.mol
Article Data: 4

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (5'-cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid benzyl ester(CAS DataBase Reference)
NIST Chemistry Reference: (5'-cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid benzyl ester(865980-39-8)
EPA Substance Registry System: (5'-cyano-4-methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-4-yl)-carbamic acid benzyl ester(865980-39-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 865980-39-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 865980-39-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,9,8 and 0 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 865980-39:
(8*8)+(7*6)+(6*5)+(5*9)+(4*8)+(3*0)+(2*3)+(1*9)=228
228 % 10 = 8
So 865980-39-8 is a valid CAS Registry Number.

865980-39-8Upstream product

33252-28-7 6-chloronicotinonitrile

865980-39-8Downstream Products

865980-39-8Relevant articles and documents

Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl] amino-4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): A very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes

Madar, David J.,Kopecka, Hana,Pireh, Daisy,Yong, Hong,Pei, Zhonghua,Li, Xiaofeng,Wiedeman, Paul E.,Djuric, Stevan W.,Von Geldern, Thomas W.,Fickes, Michael G.,Bhagavatula, Lakshmi,McDermott, Todd,Wittenberger, Steven,Richards, Steven J.,Longenecker, Kenton L.,Stewart, Kent D.,Lubben, Thomas H.,Ballaron, Stephen J.,Stashko, Michael A.,Long, Michelle A.,Wells, Heidi,Zinker, Bradley A.,Mika, Amanda K.,Beno, David W. A.,Kempf-Grote, Anita J.,Polakowski, James,Segreti, Jason,Reinhart, Glenn A.,Fryer, Ryan M.,Sham, Hing L.,Trevillyan, James M.

, p. 6416 - 6420 (2008/04/18)

Dipeptidyl peptidase-IV (DPP-IV) inhibitors are poised to be the next major drug class for the treatment of type 2 diabetes. Structure-activity studies of substitutions at the C5 position of the 2-cyanopyrrolidide warhead led to the discovery of potent inhibitors of DPP-IV that lack activity against DPP8 and DPP9. Further modification led to an extremely potent (KiDPP-IV = 1.0 nM) and selective (KiDPP8 > 30 μM; KiDPP9 > 30 μM) clinical candidate, ABT-279, that is orally available, efficacious, and remarkably safe in preclinical safety studies.

Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)

-

, (2008/06/13)

The present invention relates to compounds which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atheroscler

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