866018-46-4

Basic information

• Product Name: 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL
• Synonyms: 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL;4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-ol;Sertraline Hydrochloride Impurity H
• CAS NO: 866018-46-4
• Molecular Formula: C₁₆H₁₄Cl₂O
• Molecular Weight: 293.19
• Mol File: 866018-46-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL(866018-46-4)
• EPA Substance Registry System: 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL(866018-46-4)

Safety Data

• Hazardous Substances Data: 866018-46-4(Hazardous Substances Data)

Usage

Description

4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL is a chemical compound that serves as an intermediate in the synthesis of metabolites of Sertraline (S280000).

Uses

Used in Pharmaceutical Industry:
4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPHTHALENOL is used as a chemical intermediate for the synthesis of metabolites of Sertraline, a widely prescribed antidepressant medication. Its role in the synthesis process is crucial for the production of the final drug product, contributing to the treatment of various mental health conditions.

Upstream product

• 439134-46-0 1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene 
• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 

Downstream Products

• 439134-46-0 1-(3,4-dichlorophenyl)-1,2-dihydronaphthalene 
• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 944054-44-8 4-(3,4-dichlorophenyl)-3,4-dihydro-1H-naphthalen-2-one 
• 944054-45-9 C₁₆H₁₄Cl₂O₂ 
• 944054-67-5 C₂₃H₂₇Cl₂NO₂ 
• 944054-68-6 C₂₃H₂₇Cl₂NO₂ 
• 944053-99-0 2-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)ethanamine 
• 944054-52-8 2-(4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-2-yl)acetonitrile 
• 944054-51-7 2-(-1-(3,4-dichlorophenyl)-1,2-dihydronaphthalen-3-yl)acetonitrile 
• 944053-83-2 C₁₈H₁₉Cl₂N 
• 96850-13-4 trans-3-(3,4-dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride 

Relevant articles and documents

Sodium amalgam mediated desulfonylative reduction of α-functionalized β-ketosulfones

Sodium amalgam mediated desulfonylative reduction of β-ketosulfones in MeOH at rt affords alcohols in good yields via radical desulfonylation of β-ketosulfones and sequential Bouveault-Blanc reduction of the resulting ketones.

Iodine(III)-promoted ring contraction of 1,2-dihydronaphthalenes: A diastereoselective total synthesis of (±)-indatraline

Equation presented A new approach for the synthesis of (±)- indatraline, which is a 3-phenyl-1-indanamine that displays several biological activities, is described. The strategy features as the key step a diastereoselective ring contraction of a 1,2-dihydronaphthalene promoted by Phl(OTs)OH, to construct the indan ring system. The oxidative rearrangement of other 1,2-dihydronaphthalenes was also investigated, generalizing this method to obtain indans.