866088-07-5

Basic information

• Product Name: O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)
• Synonyms: O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)
• CAS NO: 866088-07-5
• Molecular Weight: 270.756
• Mol File: 866088-07-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)(CAS DataBase Reference)
• NIST Chemistry Reference: O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)(866088-07-5)
• EPA Substance Registry System: O-benzyl-chloroacetol methyl acetal ((2S, 4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran)(866088-07-5)

Safety Data

• Hazardous Substances Data: 866088-07-5(Hazardous Substances Data)

Upstream product

• 866088-06-4 ((2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol) 
• 100-39-0 benzyl bromide 

Downstream Products

• 866088-08-6 C₁₆H₂₂O₅ 

Relevant articles and documents

PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS, PARTICULARLY ATORVASTATIN

There is provided a process for the preparation of a compound of formula (7) or salts thereof: wherein R1 represents a hydrogen or a hydrocarbyl group, R2 represents a hydrogen or substituent group, R3 represents a hydrogen or a hydrocarbyl group, and X represents a hydrogen or substituent group which comprises a) cyanating a compound of formula (1): wherein Y represents a halo group, preferably CI or Br; P1 represents hydrogen or a protecting group, and W represents =0 or -OP2, in which P2 represents hydrogen or a protecting group, to give a compound of formula (2): b) reducing the compound of formula (2) to give a compound of formula (3): coupling the compound of formula (3) with a compound of formula (4): to give a compound of formula (5): when W represents -OP2, deprotecting and then oxidising the compound of formula (5) to give a compound of formula (6): and e) subjecting the compound of formula (5) when W represents =O, or compound of formula (6) to ring-opening, and removal of any remaining protecting groups, to give a compound of formula (7) or salts thereof.