86620-81-7

Basic information

• Product Name: 4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER
• Synonyms: AKOS B022240;4-(1-PIPERAZINYL METHYL) BENZOIC ACID METHYL ESTER;4-(1-PIPERIYL METHYL) BENZOIC ACID METHYL ESTER;4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER;ART-CHEM-BB B022240;METHYL 4-PIPERAZIN-1-YLMETHYLBENZOATE;METHYL 4-PIPERAZINE-1-YLMETHYLBENZOATE;4-(1-PIPERAZIYL METHYL) BENZOIC ACID METHYL ESTER
• CAS NO: 86620-81-7
• Molecular Formula: C₁₃H₁₈N₂O₂
• Molecular Weight: 234.29
• Product Categories: API intermediates
• Mol File: 86620-81-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 355.6 ºCat 760 mmHg
• Flash Point: 168.9 ºC
• Appearance: /
• Density: 1.117 g/cm³
• Vapor Pressure: 3.08E-05mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER(86620-81-7)
• EPA Substance Registry System: 4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER(86620-81-7)

Safety Data

• Hazardous Substances Data: 86620-81-7(Hazardous Substances Data)

Usage

General Description

4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER is a chemical compound that is derived from piperazine and benzoic acid. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and pharmaceuticals. 4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER exhibits a range of biological activities, including antipsychotic, antihistaminic, and anxiolytic effects. It is also used as a building block in the production of other organic compounds. Due to its versatile properties, 4-PIPERAZIN-1-YLMETHYL-BENZOIC ACID METHYL ESTER plays a crucial role in the development and production of numerous medications and pharmaceutical products.

InChI:InChI=1/C13H18N2O2/c1-17-13(16)12-4-2-11(3-5-12)10-15-8-6-14-7-9-15/h2-5,14H,6-10H2,1H3

Upstream product

• 110-85-0 piperazine 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 142-64-3 piperazine dihydrochloride 
• 142-63-2 piperazine hexahydrate 
• 844891-11-8 tert-butyl 4-[(4-methoxycarbonylphenyl)methyl]piperazine-1-carboxylate 
• 619-66-9 4-Carboxybenzaldehyde 
• 34040-64-7 p-methyloxycarbonylbenzyl chloride 
• 1571-08-0 methyl 4-formylbenzoate 

Downstream Products

• 86620-80-6 Methyl 4-[1-(2-hydroxypropyl)-piperazin-4-ylmethyl]-benzoate 
• 895519-97-8 4-((4-ethylpiperazin-1-yl)methyl)benzoic acid 
• 208754-40-9 4-((4-propylpiperazin-1-yl)methyl)benzoic acid 
• 415951-48-3 C₁₅H₂₂N₂O₂ 

Relevant articles and documents

Synthesis, biological evaluation, and molecular docking of ((4-([1,2,4]triazolo[4,3-b][1,2,4,5]tetrazin-6-yl) piperazin-1-yl)methyl) benzohydrazide derivatives

A series of ((4-([1,2,4]triazolo[4,3-b][1,2,4,5] methyl) benzo-hydrazide derivatives was designed, synthesized, and evaluated for their inhibition activities against five tumor cells and c-Met kinase in vitro. These compounds were fully characterized by

LPAR1 Inhibitor. Medical application and preparation method thereof

LPAR1 Inhibitor, medical application and preparation method thereof, and the structural general formula I of the inhibitor is as follows. In-flight RX Alkyl groups selected from H, C1 - C6, COOCH3 , CF3 , NO2 ,

Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization

A series of chromones, bearing substituted amino groups or N-substituted carboxamide moieties in position 2, was synthesized and characterized in cellular assays for modulation of the ABC transporters ABCC1 (MDCKII-MRP1 cells), ABCB1 (Kb-V1 cells) and ABCG2 (MCF-7/Topo cells). The most potent ABCC1 modulators identified among these flavonoid-type compounds were comparable to the reference compound reversan regarding potency, but superior in terms of selectivity concerning ABCB1 and ABCG2 (2-[4-(Benzo[c][1,2,5]oxadiazol-5-ylmethyl)piperazin-1-yl]-5,7-dimethoxy-4H-chromen-4-one (51): ABCC1, IC50 11.3-1/4M; inactive at ABCB1 and ABCG2). Compound 51 was as effective as reversan in reverting ABCC1-mediated resistance to cytostatics in MDCKII-MRP1 cells and proved to be stable in mouse plasma and cell culture medium. Modulators, such as compound 51, are of potential value as pharmacological tools for the investigation of the (patho)physiological role of ABCC1.