866252-52-0 Usage
Description
4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is a chemical compound with the molecular formula C11H15F3O5SSi. It is a derivative of phenyl trifluoromethanesulfonate, containing two methoxy groups and a trimethylsilyl group attached to the phenyl ring. 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is a colorless liquid that is sensitive to air and moisture, requiring handling and storage under inert gas conditions.
Uses
Used in Pharmaceutical Research:
4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate is used as a reagent in organic synthesis for the introduction of the triflate group to nucleophiles. This facilitates various chemical reactions such as substitution, elimination, and palladium-catalyzed cross-coupling reactions, which are crucial in the synthesis of complex organic molecules.
Used in Organic Synthesis:
In the field of organic synthesis, 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate serves as a valuable reagent to modify and functionalize organic compounds. Its ability to introduce the triflate group to nucleophiles aids in the formation of new chemical bonds and the construction of intricate molecular structures.
Used in Other Industries:
Beyond pharmaceutical research and organic synthesis, 4,5-Dimethoxy-2-(trimethylsilyl)phenyl Trifluoromethanesulfonate finds applications in other industries where complex organic molecules are synthesized and utilized. Its versatility as a reagent makes it a valuable tool for advancing chemical research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 866252-52-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,2,5 and 2 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 866252-52:
(8*8)+(7*6)+(6*6)+(5*2)+(4*5)+(3*2)+(2*5)+(1*2)=190
190 % 10 = 0
So 866252-52-0 is a valid CAS Registry Number.
InChI:InChI=1/C12H17F3O5SSi/c1-18-8-6-10(20-21(16,17)12(13,14)15)11(22(3,4)5)7-9(8)19-2/h6-7H,1-5H3
866252-52-0Relevant articles and documents
Trifluoromethyl aryl sulfonates (TFMS): An applicable trifluoromethoxylation reagent
Lei, Meng,Miao, Hang,Wang, Xueyuan,Zhang, Wen,Zhu, Chengjian,Lu, Xiaqiang,Shen, Jian,Qin, Yanru,Zhang, Haoyang,Sha, Sijia,Zhu, Yongqiang
, p. 1389 - 1392 (2019/04/30)
Fluorine is probably another favorite hetero-atom for incorporation into small molecules after nitrogen. Among many fluorine-containing groups, trifluoromethyl aryl ethers (ArOCF3) have unique properties in drug design and are difficult to be synthesized, and many different methods were developed to prepare them. A novel one-pot synthesis of o-iodine-aryl trifluoromethyl ethers (ArOCF3I) was described by the reaction of trifluoromethoxylation and iodination with trifluoromethyl aryl sulfonates (TFMS) in this manuscript. The reaction conditions were optimized by screening different solvents, crown ethers, substrates and the ratios and the yields of products were in moderate to high yields (up to 86%).
Synthesis method of calmodulin inhibitor for treating brain-derived diseases
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Paragraph 0027; 0028; 0029, (2017/08/29)
The invention discloses a synthesis method of a calmodulin inhibitor for treating brain-derived diseases and belongs to the technical field of synthesis of chemicals. The technical scheme is characterized in that a synthetic route of the synthesis method
