86646-83-5

Basic information

• Product Name: methyl 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate
• Synonyms: 2H-1-benzopyran-2-carboxylic acid, 3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-, methyl ester
• CAS NO: 86646-83-5
• Molecular Formula: C₁₅H₂₀O₄
• Molecular Weight: 264.3169
• Mol File: 86646-83-5.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 393.473°C at 760 mmHg
• Flash Point: 142.321°C
• Density: 1.146g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.536
• CAS DataBase Reference: methyl 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate(86646-83-5)
• EPA Substance Registry System: methyl 6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate(86646-83-5)

Safety Data

• Hazardous Substances Data: 86646-83-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 203861-27-2 6-Hydroxy-2,5,7,8-tetramethyl-chroman-2-carboxylic acid methoxycarbonylmethyl ester 
• 50-00-0 formaldehyd 
• 700-13-0 Trimethylhydroquinone 
• 80-62-6 methacrylic acid methyl ester 
• 56305-04-5 trolox 
• 186581-53-3 diazomethane 
• 74-88-4 methyl iodide 
• 25809-98-7 2-dimethylaminomethyl-3,5,6-trimethylhydroquinone 

Downstream Products

• 210174-90-6 methyl-6-(benzyloxy)-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromene-2-carboxylate 
• 56305-04-5 trolox 
• 24960-03-0 (S)-2,5,7,8-tetramethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol 
• 1721-51-3 alpha-tocotrienol 
• 106461-96-5 (+/-)-3,4-dihydro-6-methoxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-carboxilic acid 

Relevant articles and documents

Convenient preparation of 2,7,8-trimethyl-6-hydroxychroman-2-carboxylic acid (γ-trolox)

The title chroman is useful in synthesis and as a water-soluble analog of γ-tocopherol, a member of the vitamin E family. This new synthesis of γ-trolox proceeds via selective aromatic demethylation of Trolox, the more easily available 2,5,7,8-tetramethyl homolog compound. This route is shorter than the previous synthesis, avoids the use of cyanide and methoxybutadiene, and requires no chromatography. Copyright Taylor & Francis Group, LLC.

Design, Synthesis, and Anticancer Evaluation of Novel Benzopyran 1, 3, 4-oxadiazole Derivatives

Some new benzopyran 1,3,4-oxadiazole, derivatives (PKO 1-7) were designed by docking, in silico absorption, distribution, metabolism, excretion (ADME) and predicted toxicity studies, and then synthesized by S-alkylation of benzopyran 1,3,4-oxadiazole with

Covalent and Ionic Conjugates of Trolox and α-Tocopherol with 1-Aminoadamantane

Covalent, ionic, and ionic-covalent conjugates of trolox and α-tocopherol with 1-aminoadamantane were synthesized. Their structures were elucidated using mass spectrometry and IR, PMR, and 13C NMR spectroscopy. The water solubility of the ionic trolox conjugates with 1-aminoadamantane increased by 2–24 times as compared with that of trolox whereas that of the α-tocopherol succinate conjugates remained the same as that of α-tocopherol.