866464-53-1

Basic information

• Product Name: Glycine, N-[(3-chlorophenyl)methylene]-, methyl ester
• CAS NO: 866464-53-1
• Molecular Formula: C10H10ClNO2
• Molecular Weight: 211.648
• Mol File: 866464-53-1.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: Glycine, N-[(3-chlorophenyl)methylene]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[(3-chlorophenyl)methylene]-, methyl ester(866464-53-1)
• EPA Substance Registry System: Glycine, N-[(3-chlorophenyl)methylene]-, methyl ester(866464-53-1)

Safety Data

• Hazardous Substances Data: 866464-53-1(Hazardous Substances Data)

Upstream product

• 5680-79-5 glycine ethyl ester hydrochloride 
• 587-04-2 m-Chlorobenzaldehyde 

Downstream Products

• 1221507-59-0 (2S,3S,5S)-4,4-di-tert-butyl 2-methyl 5-(3-chlorophenyl)-3-phenylpyrrolidine-2,4,4-tricarboxylate 
• 1310576-73-8 trimethyl (2R,3R,5R)-5-(3-chlorophenyl)-3-phenylpyrrolidine-2,4,4-tricarboxylate 
• 1373444-84-8 trimethyl (2S,3R,4S,5R)-5-(3-chlorophenyl)pyrrolidine-2,3,4-tricarboxylate 
• 1417912-32-3 (2R,4S,5R)-dimethyl 5-(3-chlorophenyl)-4-fluoropyrrolidine-2,4-dicarboxylate 
• 1333395-39-3 (2'R,3R,4'R,5'R)-methyl 2'-(3-chlorophenyl)-4-oxo-4'-phenylspiro[chroman-3,3'-pyrrolidine]-5'-carboxylate 
• 1319726-79-8 (1R,3R,4R,5R)-methyl 1-(3-chlorophenyl)-6-oxo-4-phenyl-2-azaspiro[4.4]nonane-3-carboxylate 
• 1195786-08-3 4-tert-butyl 2-methyl (2R,4R,5S)-5-(3-chlorophenyl)pyrrolidine-2,4-dicarboxylate 
• 1195786-24-3 4-tert-butyl 2-methyl (2S,4S,5R)-5-(3-chlorophenyl)pyrrolidine-2,4-dicarboxylate 

Relevant articles and documents

Copper/GanPhos-Catalyzed 1,3-Dipolar Cycloaddition of Azo?-methine Ylides: An Efficient Access to Chiral Pyrrolidine Spirocycles

A highly efficient copper/GanPhos-catalyzed 1,3-dipolar cyclo?-addition?-of azomethine ylides is reported. This viable transformation provides a series of optically active spiro[dihydronaphthalene-2,3′-pyrrolidine]s, bearing one spiro quaternary and three tertiary stereogenic centers, in good yields and with high ee values. This protocol features high diastereo- A nd enantioselectivity, broad substrate scope and mild reaction conditions.

Facile synthesis of chiral [2,3]-fused hydrobenzofuran: Via asymmetric Cu(i)-catalyzed dearomative 1,3-dipolar cycloaddition

Intermolecular asymmetric dearomative 1,3-dipolar cycloaddition of 2-nitrobenzofurans with azomethine ylides was enabled by using a chiral Cu(i)/(S,Sp)-iPr-Phosferrox catalyst. As a result, a series of highly stereoselective chiral [2,3]-fused hydrobenzofurans possessing four contiguous stereogenic centers were obtained with good to high yields, diastereoselectivities and enantioselectivities. The reaction has broad substrate scope tolerating various functional groups.

Tandem nucleophilic addition-cycloaddition of arynes with α-iminoesters: Two concurrent pathways to imidazolidines

The tandem nucleophilic addition-cycloaddition reaction has been developed for the synthesis of functionalized imidazolidine derivatives. A variety of α-iminoesters and aryne precursors were well tolerated under the mild reaction conditions. This asymmetric cycloaddition afforded imidazolidine derivatives with high yields, complete regioselectivities, and excellent diastereo- and enantioselectivities. Aryne-induced ylides working as 1,3-dipoles for asymmetric cycloaddition are the notable feature of the present reaction. In the tandem reaction, the [3+2] cycloaddition of aryne-induced ylides with metallized α-iminoesters and metal-catalyzed [3+2] cycloaddition of azomethine ylide with α-iminoesters are two concurrent pathways to imidazolidines.