866523-71-9

Basic information

• Product Name: 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide
• Synonyms: 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide
• CAS NO: 866523-71-9
• Molecular Weight: 424.375
• Mol File: 866523-71-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide(866523-71-9)
• EPA Substance Registry System: 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide(866523-71-9)

Safety Data

• Hazardous Substances Data: 866523-71-9(Hazardous Substances Data)

Upstream product

• 866523-70-8 C₁₈H₁₈Cl₂N₂O₂S 
• 867-44-7 S-Methylisothiourea sulfate 
• 4066-41-5 5-acetylthiophene-2-carboxylic acid 
• 866523-73-1 5-(3-dimethylaminoacryloyl)thiophene-2-carboxylic acid methyl ester 
• 908834-77-5 5-(2-methylsulfanyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid methyl ester 
• 52516-13-9 2-(2,4-dichloro-phenyl)-ethylamine 

Downstream Products

• 866523-72-0 5-(2-methanesulfonyl-pyrimidin-4-yl)-thiophene-2-carboxylic acid [2-(2,4-dichloro-phenyl)-ethyl]-amide 

Relevant articles and documents

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies

A series of 2-pyrimidyl-5-amidothiophenes has been synthesized and evaluated for AKT inhibition. SAR studies resulted in potent inhibitors of AKT with IC50 values as low as single digit nanomolar as represented by compound 2aa. Compound 2aa sho