86653-00-1Relevant articles and documents
DIANIONS OF β-HYDROXY SULFONES: NEW AND GENERAL APPROACH TO SELECTIVE SYNTHESIS OF 2(5H)-FURANONES
Tanaka, Kazuhiko,Ootake, Kazuhiko,Imai, Keisuke,Tanaka, Nobuo,Kaji, Aritsune
, p. 633 - 636 (2007/10/02)
Dianions derived from β-hydroxy sulfones are highly reactive toward a variety of electrophiles including alkyl halides, carbonyl compounds, and sodium iodoacetate.A convenient synthetic method for 4-alkyl- and 5-alkyl-2(5H)-furanones has been developed by using these dianions.A new synthetic approach to trans,3,4-bis(3-hydroxybenzyl)dihydro-2(3H)-furanone, the first lignan found in humans, via a facile reduction of 2(5H)-furanone with Mg-methanol is also described.
