866993-99-9

Basic information

• Product Name: 3-(2-hydroxy-5-methylphenyl)-1-methyl-3-phenyl-1,3-dihydroindol-2-one
• Synonyms: 3-(2-hydroxy-5-methylphenyl)-1-methyl-3-phenyl-1,3-dihydroindol-2-one
• CAS NO: 866993-99-9
• Molecular Weight: 329.398
• Mol File: 866993-99-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2-hydroxy-5-methylphenyl)-1-methyl-3-phenyl-1,3-dihydroindol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-hydroxy-5-methylphenyl)-1-methyl-3-phenyl-1,3-dihydroindol-2-one(866993-99-9)
• EPA Substance Registry System: 3-(2-hydroxy-5-methylphenyl)-1-methyl-3-phenyl-1,3-dihydroindol-2-one(866993-99-9)

Safety Data

• Hazardous Substances Data: 866993-99-9(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 20423-52-3 3-chloro-1-methyl-3-phenyl-1,3-dihydroindol-2-one 
• 39531-24-3 5-methyl-3-phenyl-1-benzofuran-2(3H)-one 
• 100-61-8 N-methylaniline 
• 15757-32-1 3-hydroxy-1-methyl-3-phenyl-1,3-dihydro-2H-indol-2-one 

Downstream Products

• 912296-57-2 3-(2-hydroxy-5-methylphenyl)-1-methyl-3-phenyl-1,3-dihydroindole-2-thione 

Relevant articles and documents

I2-Mediated Cross-Dehydrogenative Coupling and Amidation of 3-Aryl Benzofuranones with Aryl Amines for the Synthesis of 3,3-Diaryl Indolin-2-ones

We have developed a protocol for efficient synthesis of indolin-2-ones from benzofuranones and aryl amines using iodine as a mediator. A diverse range of benzofuranones and aryl amines undergo cross-dehydrogenative coupling and amidation of 3-aryl benzofuranones for the cascade reaction to generate products in 24-93% yields. This reaction can be easily scaled-up to give an indolin-2-one in a gram scale. Further chemical manipulation of the products enabled useful transformations of the phenol ring including alkylation, arylation, etc.

A mild thermal and acid-catalyzed rearrangement of O-aryl ethers into ortho-hydroxy arenes

(Chemical Equation Presented) An unusual rearrangement of an O-aryl ether to an ortho-hydroxyaryl system was discovered during our studies on the synthesis of diazonamide A. We discuss the exploration of this rearrangement under mild thermal and both Bron