867259-20-9Relevant articles and documents
Synthesis and properties of a novel molecular beacon containing a benzene-phosphate backbone at its stem moiety
Ueno, Yoshihito,Kawamura, Akihiro,Takasu, Keiji,Komatsuzaki, Shinji,Kato, Takumi,Kuboe, Satoru,Kitamura, Yoshiaki,Kitade, Yukio
experimental part, p. 2761 - 2769 (2009/09/08)
This paper describes the synthesis and properties of a novel molecular beacon (MB) containing a benzene-phosphate backbone at its stem moiety. The fluorescence intensity of MBs was found to stabilize by the introduction of the benzene-phosphate backbone at its stem moiety. Furthermore, an MB containing the benzene-phosphate backbone was more resistant to DNase I (endonuclease) than an MB comprising natural DNA and 2′-O-methyl-RNA. These results indicate that the MB with the benzene-phosphate backbone is superior as a molecular beacon as compared to the MB composed of natural DNA and 2′-O-methyl-RNA. The Royal Society of Chemistry 2009.